Evidence map›Paper›PMID 40254333›Full record

ArticleBMJ mental health2025

Access to treatment protocols and manuals for evidence-based psychological interventions for severe mental disorders: a survey of randomised trials included in network meta-analyses.

Chrysanthi Blithikioti, Giuliano Tomei, Fabrizio Visconti, Lorena Pizzocri, Camilla Cadorin, Irene Gómez-Gómez, Ioana Alina Cristea

Abstract read
In one paragraph

Article in BMJ mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chrysanthi BlithikiotiDipartimento di Psicologia Generale, Università degli Studi di Padova , Padua, Italy.ORCID 0000-0003-4569-9639
Giuliano TomeiDipartimento di Psicologia Generale, Università degli Studi di Padova , Padua, Italy.ORCID 0000-0002-1516-1830
Fabrizio ViscontiDipartimento di Psicologia Generale, Università degli Studi di Padova , Padua, Italy.ORCID 0009-0007-2774-8616
Lorena PizzocriDipartimento di Psicologia Generale, Università degli Studi di Padova , Padua, Italy.ORCID 0009-0003-5293-6038
Camilla CadorinDipartimento di Psicologia Generale, Università degli Studi di Padova , Padua, Italy.ORCID 0000-0002-7642-2096
Irene Gómez-GómezUniversidad Loyola Andalucía, Departamento de Psicología, Córdoba, Spain.ORCID 0000-0001-8014-6955
Ioana Alina CristeaDipartimento di Psicologia Generale, Università degli Studi di Padova , Padua, Italy ioanaalina.cristea@unipd.it.ORCID 0000-0002-9854-7076

Funding

European Union (EU) Horizon Europe European Research Council (ERC) 101042701
6 · The paper itself

Abstract

backgroundEvidence-based psychological interventions for mental disorders are described in treatment protocols and manuals, which detail treatment components and conditions of application. Systematic evaluations of the accessibility of treatment protocols and manuals across multiple mental disorders are absent.

objectiveWe assessed whether treatment protocols or manuals for psychological interventions for severe mental disorders are accessible and publicly available. STUDY SELECTION AND ANALYSIS: We surveyed randomised controlled trials (RCTs) from six large network meta-analyses of psychological interventions for severe mental disorders (psychotic, borderline personality, substance use, bipolar, anorexia and bulimia nervosa). Between January 2024 and February 2025, we retrieved protocols and manuals of psychological intervention arms using a multipronged approach (published protocol, trial registries, author contact, commercial availability). We report the proportion of trials and intervention arms for which protocols or manuals were (1) Accessible, that is, retrievable by any method, and (2) Publicly versus commercially available.

findingsWe included 260 RCTs, with 422 active intervention arms. We retrieved published protocols for 20 RCTs (8%, 95% CI 5% to 12%) and contacted 450 authors for the remaining 240. Authors shared protocols for 43/240 trials (18%, 95% CI 13% to 23%), refused to share for 73 (30%, 95% CI 25% to 37%) and did not respond for 101 (42%, 95% CI 36% to 49%). Protocols or manuals were retrievable for 364 psychological intervention arms (86%, 95% CI 83% to 89%), with 191 available commercially (45%, 95% CI 40% to 50%) and 106 (25%, 95% CI 21% to 30%) publicly. CONCLUSIONS AND CLINICAL IMPLICATIONS: Retrieving detailed descriptions of psychological interventions used in trials, crucial for identifying treatment components, was challenging, resource-intensive and required multiple methods. Reliance on public availability and author sharing enabled access to about 40% of protocols or manuals.

Indexed as

Clinical ProtocolsHealth Services AccessibilityManuals as TopicMental DisordersPsychosocial InterventionRandomized Controlled Trials as TopicHumansNetwork Meta-Analysis as TopicData Interpretation, StatisticalEating disordersPersonality disordersSchizophrenia & psychotic disordersSubstance misuse

Identifiers

PMID40254333
PMCPMC12010291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.