Evidence map›Paper›PMID 40254328›Full record

ArticleSaudi medical journal2025

Validation of DIGIROP- Birth and DIGIROP- Screen for the discovery of retinopathy of prematurity requiring treatment in preterm births in Saudi Arabia.

Huda K Ahmedhussain, Lina H Raffa, Amal M Alosaimif, Sarah K Alessa, Suzan Y Alharbi, Hashem Almarzouki, Mansour A AlQurashi

Abstract readValidation Study
In one paragraph

Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huda K AhmedhussainFrom the Department of Ophthalmology (Ahmedhussain, Raffa, Alessa), King Abdulaziz University Hospital, from the Faculty of Medicine (Ahmedhussain, Raffa, Alessa), King Abdulaziz University, from the Department of Obstetrics and Gynecology (Alosaimi); from the Department of Ophthalmology (Almarzouki); from the Department of Pediatrics (AlQurashi), Neonatology Division, King Abdulaziz Medical City, from the Department of Ophthalmology (Alharbi), Jeddah Eye Hospital, from the College of Medicine (Almarzouki, AlQurashi), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Almarzouki, AlQurashi), Ministry of National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.
Lina H RaffaFrom the Department of Ophthalmology (Ahmedhussain, Raffa, Alessa), King Abdulaziz University Hospital, from the Faculty of Medicine (Ahmedhussain, Raffa, Alessa), King Abdulaziz University, from the Department of Obstetrics and Gynecology (Alosaimi); from the Department of Ophthalmology (Almarzouki); from the Department of Pediatrics (AlQurashi), Neonatology Division, King Abdulaziz Medical City, from the Department of Ophthalmology (Alharbi), Jeddah Eye Hospital, from the College of Medicine (Almarzouki, AlQurashi), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Almarzouki, AlQurashi), Ministry of National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0001-8211-2353
Amal M AlosaimifFrom the Department of Ophthalmology (Ahmedhussain, Raffa, Alessa), King Abdulaziz University Hospital, from the Faculty of Medicine (Ahmedhussain, Raffa, Alessa), King Abdulaziz University, from the Department of Obstetrics and Gynecology (Alosaimi); from the Department of Ophthalmology (Almarzouki); from the Department of Pediatrics (AlQurashi), Neonatology Division, King Abdulaziz Medical City, from the Department of Ophthalmology (Alharbi), Jeddah Eye Hospital, from the College of Medicine (Almarzouki, AlQurashi), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Almarzouki, AlQurashi), Ministry of National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.
Sarah K AlessaFrom the Department of Ophthalmology (Ahmedhussain, Raffa, Alessa), King Abdulaziz University Hospital, from the Faculty of Medicine (Ahmedhussain, Raffa, Alessa), King Abdulaziz University, from the Department of Obstetrics and Gynecology (Alosaimi); from the Department of Ophthalmology (Almarzouki); from the Department of Pediatrics (AlQurashi), Neonatology Division, King Abdulaziz Medical City, from the Department of Ophthalmology (Alharbi), Jeddah Eye Hospital, from the College of Medicine (Almarzouki, AlQurashi), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Almarzouki, AlQurashi), Ministry of National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.
Suzan Y AlharbiFrom the Department of Ophthalmology (Ahmedhussain, Raffa, Alessa), King Abdulaziz University Hospital, from the Faculty of Medicine (Ahmedhussain, Raffa, Alessa), King Abdulaziz University, from the Department of Obstetrics and Gynecology (Alosaimi); from the Department of Ophthalmology (Almarzouki); from the Department of Pediatrics (AlQurashi), Neonatology Division, King Abdulaziz Medical City, from the Department of Ophthalmology (Alharbi), Jeddah Eye Hospital, from the College of Medicine (Almarzouki, AlQurashi), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Almarzouki, AlQurashi), Ministry of National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.
Hashem AlmarzoukiFrom the Department of Ophthalmology (Ahmedhussain, Raffa, Alessa), King Abdulaziz University Hospital, from the Faculty of Medicine (Ahmedhussain, Raffa, Alessa), King Abdulaziz University, from the Department of Obstetrics and Gynecology (Alosaimi); from the Department of Ophthalmology (Almarzouki); from the Department of Pediatrics (AlQurashi), Neonatology Division, King Abdulaziz Medical City, from the Department of Ophthalmology (Alharbi), Jeddah Eye Hospital, from the College of Medicine (Almarzouki, AlQurashi), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Almarzouki, AlQurashi), Ministry of National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.
Mansour A AlQurashiFrom the Department of Ophthalmology (Ahmedhussain, Raffa, Alessa), King Abdulaziz University Hospital, from the Faculty of Medicine (Ahmedhussain, Raffa, Alessa), King Abdulaziz University, from the Department of Obstetrics and Gynecology (Alosaimi); from the Department of Ophthalmology (Almarzouki); from the Department of Pediatrics (AlQurashi), Neonatology Division, King Abdulaziz Medical City, from the Department of Ophthalmology (Alharbi), Jeddah Eye Hospital, from the College of Medicine (Almarzouki, AlQurashi), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Almarzouki, AlQurashi), Ministry of National Guard Health Affairs, Jeddah, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo validate 2 DIGIROP prediction models for retinopathy of prematurity (ROP) type 1 and compare them to other weight-based algorithms in a premature Saudi Arabian infant cohort.

methodsPreterm infants of 24-30 weeks' gestational age (GA) or body weight (BW) of ≤1500g who were admitted to the neonatal units of 2 Jeddah tertiary centers between January 2015 and September 2021 were included (N=363). The DIGIROP-Birth employed the birth GA, gender, birth weight, and age at ROP onset as predictors. The area under the receiver operating characteristic curve (AUC) with 95% confidence interval, specificity, and sensitivity were projected. The DIGIROP-Screen risk of risk were identified at 6-14 weeks postnatal age (PNA).

resultsThe mean GA was 27.94±1.6 weeks and the mean BW was 1068.2±269.2 g. The DIGIROP-Birth had a sensitivity of 93.8%; specificity of 48.9%; AUC of 0.70; and accuracy of 52.9%. For DIGIROP-Screen, the AUC for models spanning PNA 6-14 weeks varied from 0.68-0.83, and sensitivity varied from 73.3-96.8%. The DIGIROP-Birth and DIGIROP-Screen showed the highest accuracy and AUC value in comparison to other ROP prediction models.

conclusionThe 2 models demonstrated high predictive capacity for type 1 ROP risk assessment in this cohort. The potential of these tools for identifying high-risk infants and avoiding standard ROP screening in low-risk infants needs to be verified through large-scale studies.

Indexed as

Neonatal ScreeningRetinopathy of PrematurityAlgorithmsBirth WeightFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMaleRisk AssessmentROC CurveSaudi ArabiaSensitivity and SpecificityalgorithmsCO-ROPG-ROPROPscoreWINROP

Identifiers

PMID40254328
PMCPMC12010494

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.