Evidence map›Paper›PMID 40254327›Full record

ArticleSaudi medical journal2025

Risk of malignancy in thyroid nodules Bethesda III sub classification into nuclear atypia and architectural atypia.

Fahad Alwadi, Mohammed Alessa, Elaf Abdulkarim Alamer, Hamad F Alrabiah, Abdulaziz Alaraifi, Abdulaziz Alsalem, Majed Mohamed Pharaon, Rahaf Khalid Alhabib

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Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fahad AlwadiFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
Mohammed AlessaFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
Elaf Abdulkarim AlamerFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0002-4888-5392
Hamad F AlrabiahFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
Abdulaziz AlaraifiFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
Abdulaziz AlsalemFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
Majed Mohamed PharaonFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
Rahaf Khalid AlhabibFrom the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify the risk of malignancy in the Bethesda III category based on histopathological subclassification.

methodsWe retrospectively analyzed 193 patients with Bethesda III thyroid nodules who underwent surgical resection. The primary outcome was the malignancy risk associated with each histopathological sub-classification.

resultsOf 193 patients, final histopathology revealed malignant nodules in 96 (49.7%). The malignancy rates varied among the Bethesda III subcategories, with Hürthle cell atypia of undetermined significance demonstrating the highest rate (55.6%), followed by cytological atypia (55.4%), architectural atypia (50.6%), and combined cytological and architectural atypia (33.3%). However, no significant difference in malignancy rates was observed among the Bethesda III subcategories (

conclusionBethesda III nodules pose a clinical challenge. Our findings indicate a higher risk of malignancy in patients with cytologic atypia. Bethesda III subclassification may improve clinical decisions and interdisciplinary communication.

Indexed as

Thyroid NeoplasmsThyroid NoduleAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsThyroid Cancer, PapillaryYoung Adultatypia of undetermined significancefollicular lesion of undetermined significancethyroid cancerthyroid neoplasmsthyroid nodule

Identifiers

PMID40254327
PMCPMC12010493

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