Evidence map›Paper›PMID 40254301›Full record

ArticleBMJ open2025

Improving and preserving cardiorespiratory fitness, muscle strength and adiposity through a complex lifestyle intervention in community-dwelling older adults with elevated cardiometabolic risk: study protocol for the RESTART randomised controlled trial.

Jonas Johansson, Trygve Sigvart Deraas, Laila Arnesdatter Hopstock, André Henriksen, Sameline Grimsgaard

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06122441 (RE-inventing Strategies for Healthy Ageing; Recommendations and Tools), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06122441 naactive not recruitingnot on this map

RE-inventing Strategies for Healthy Ageing; Recommendations and Tools (RESTART) - a Randomized Controlled Trial Testing a Complex Lifestyle Intervention in Older Adults at Increased Risk for Cardiometabolic Disease

TypeinterventionalSponsorUniversity of TromsoRan2024 to 2027Enrolled119ConditionsLifestyle, Healthy, Muscle Weakness, Abdominal Obesity, Cardiometabolic SyndromeArmsComplex lifestyle intervention, Physical activity monitoring and recommendations
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonas JohanssonDepartment of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway jonas.johansson@uit.no.ORCID http://orcid.org/0000-0001-7912-5786
Trygve Sigvart DeraasDepartment of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.
Laila Arnesdatter HopstockDepartment of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, Norway.ORCID http://orcid.org/0000-0003-0072-7421
André HenriksenDepartment of Computer Science, UiT The Arctic University of Norway, Tromso, Norway.ORCID http://orcid.org/0000-0002-0918-7444
Sameline GrimsgaardDepartment of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAs the global population ages, the incidence of cardiometabolic diseases and associated healthcare costs rise. There is a critical need for preventive interventions enabling long-lasting treatment effects to address the decline in physical performance and metabolic health among older adults. The RESTART (RE-inventing Strategies for healthy Ageing: Recommendations and Tools) randomised controlled trial (RCT) aims to evaluate whether a complex lifestyle intervention can improve and maintain cardiorespiratory fitness, muscle strength and body composition among older adults with elevated cardiometabolic risk. METHODS AND ANALYSIS: This is the study protocol for the RESTART trial, a two-arm, open-label, parallel-group RCT conducted in Tromsø, Norway, targeting adults aged 60-75 with obesity, a sedentary lifestyle and high cardiovascular risk. Participants are block-randomised (1:1) into either an intervention or active control group. The initial intervention phase (12 months) includes: (a) supervised high-intensity aerobic and strength training (≥85% of maximum capacity) performed two times weekly, (b) behavioural counselling based on acceptance and commitment therapy during six group sessions and (c) dietary guidance based on national nutrition recommendations during two group/two individual sessions. After 12 months, participants are gradually introduced to exercise sessions offered by local organisations and fitness centres, to enable independent maintenance of lifestyle change. The primary outcome is a change in cardiorespiratory fitness (V̇O ETHICS AND DISSEMINATION: Ethical approval for the RESTART trial was obtained from the Regional Committee for Medical Research Ethics in Northern Norway. Results will be disseminated through peer-reviewed publications, conferences and community-based channels targeting older adults, healthcare providers and municipal health organisations. This trial will also inform public health strategies for lifestyle interventions among ageing populations. TRIAL REGISTRATION NUMBER: NCT06122441.

Indexed as

AdiposityCardiorespiratory FitnessCardiovascular DiseasesMuscle StrengthObesityAgedBody CompositionCardiometabolic Risk FactorsExerciseFemaleHumansIndependent LivingLife StyleMaleMiddle AgedNorwayAgingBehaviorExerciseNUTRITION & DIETETICSPrimary PreventionRandomized Controlled Trial

Identifiers

PMID40254301
PMCPMC12010311

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.