Evidence map›Paper›PMID 40254098›Full record

ArticleNeurobiology of disease2025

Contributions of major tau kinase activation and phospho-tau accumulation to cortical and hippocampal tangle formation and cognition in older adults.

Elena Hernández-Hernández, Vladislav A Petyuk, Júlia Valor-Blanquer, Fernando Yáñez-Gómez, Alasdair M Barr, Philip L De Jager, Er-Yun Chen, Sue E Leurgans, Julie A Schneider, David A Bennett and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elena Hernández-HernándezDepartment of Pharmacology, University of the Basque Country (UPV/EHU), Leioa, Spain; Biobizkaia Health Research Institute, Barakaldo, Spain; IUNICS, University of the Balearic Islands, Palma, Spain. Electronic address: elena.hernandezh@ehu.eus.
Vladislav A PetyukPacific Northwest National Laboratory, Richland, WA, USA. Electronic address: Vladislav.Petyuk@pnnl.gov.
Júlia Valor-BlanquerDepartment of Pharmacology, University of the Basque Country (UPV/EHU), Leioa, Spain; Biobizkaia Health Research Institute, Barakaldo, Spain. Electronic address: jvalor002@ikasle.ehu.eus.
Fernando Yáñez-GómezIUNICS, University of the Balearic Islands, Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain; Department of Medicine, University of the Balearic Islands, Palma, Spain. Electronic address: f.yanez@uib.es.
Alasdair M BarrBC Mental Health and Substance Use Services Research Institute, Vancouver, BC, Canada; Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, BC, Canada. Electronic address: al.barr@ubc.ca.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology and The Taub Institute for the Study of Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA. Electronic address: pld2115@cumc.columbia.edu.
Er-Yun ChenRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA,. Electronic address: Er-Yun_Chen@rush.edu.
Sue E LeurgansRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA,. Electronic address: Sue_E_Leurgans@rush.edu.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA,. Electronic address: Julie_A_Schneider@rush.edu.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA,. Electronic address: David_A_Bennett@rush.edu.
William G HonerBC Mental Health and Substance Use Services Research Institute, Vancouver, BC, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada,. Electronic address: bill.honer@ubc.ca.
M Julia García-FusterIUNICS, University of the Balearic Islands, Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain; Department of Medicine, University of the Balearic Islands, Palma, Spain. Electronic address: j.garcia@uib.es.
Alfredo Ramos-MiguelDepartment of Pharmacology, University of the Basque Country (UPV/EHU), Leioa, Spain; Biobizkaia Health Research Institute, Barakaldo, Spain; Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Leioa, Spain. Electronic address: alfredo.ramos@ehu.eus.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Epidemiologic Study of TDP-43 Pathology in Aging and DementiaR01AG042210 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI SCHNEIDER, JULIE A. · 2012 to 2018
$2.4M
NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG042210
6 · The paper itself

Abstract

Aberrant activation of tau kinases (tauK) has been proposed as a major step in tau hyperphosphorylation and misfolding, and subsequent formation of neurofibrillary tangles (NFT) in Alzheimer's disease (AD). However, evidence of tauK hyperactivation in actual AD brains is scarce and inconsistent, and their role in age-related cognitive decline remains undocumented. We evaluated activated/inhibited species of CDK5/p35/p25, GSK3α/β, and ERK1/2 as well as ten tau/phospho-tau (ptau) peptides (mapping Ser

Indexed as

AgingCerebral CortexCognitionHippocampusNeurofibrillary TanglesPrefrontal Cortextau ProteinsAgedAged, 80 and overCognitive DysfunctionCyclin-Dependent Kinase 5FemaleGlycogen Synthase Kinase 3HumansMalePhosphorylationCyclin-Dependent Kinase 5Glycogen Synthase Kinase 3tau-protein kinasetau ProteinsAlzheimer's diseaseCDK-5ERK1/2GSK-3betaHuman brainNeurofibrillary tanglesp25/p35PhosphotauTau kinaseWorking memory

Identifiers

PMID40254098
PMCPMC12779291

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.