Evidence map›Paper›PMID 40253992›Full record

ReviewBioorganic & medicinal chemistry2025

Antitumor and immunomodulatory activities of diphyllin and its derivatives.

Yulin Ren, Judith C Gallucci, Jianhua Yu, Joanna E Burdette, James R Fuchs, A Douglas Kinghorn

Abstract readReview
In one paragraph

Review in Bioorganic & medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. NaFrontiers in chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yulin RenDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
Judith C GallucciDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
Jianhua YuDivision of Hematology & Oncology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, CA 92697, United States; The Clemons Family Center for Transformative Cancer Research, Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA 92697, United States.
Joanna E BurdetteDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, United States.
James R FuchsDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States.
A Douglas KinghornDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States. Electronic address: kinghorn.4@osu.edu.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
NCI NIH HHS P01 CA125066NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

Immune surveillance plays a key role in controlling tumor formation and development, and immune cell-based therapies, such as chimeric antigen receptor (CAR)-T cells and CAR-natural killer (NK) cells, have become important for the treatment of cancer. The proton pump (PP), vacuolar H

Indexed as

Antineoplastic AgentsImmunologic FactorsNeoplasmsAnimalsHumansLignansMolecular StructureStructure-Activity RelationshipVacuolar Proton-Translocating ATPasesAntineoplastic AgentsdiphyllinImmunologic FactorsLignansVacuolar Proton-Translocating ATPasesCancer immunotherapyCAR-T and CAR-NKDiphyllinEtoposidePhyllanthusmins

Identifiers

PMID40253992
PMCPMC12117542

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.