Evidence map›Paper›PMID 40253812›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2025

Decoding unintentional weight loss: How the right questions make a difference.

Jos W Borkent, Barbara S van der Meij, Marian A E de van der Schueren

Abstract read
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Jos W BorkentDepartment of Nutrition, Dietetics and Lifestyle, School of Allied Health, HAN University of Applied Sciences, Nijmegen, the Netherlands; Department of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands. Electronic address: jos.borkent@han.nl.
Barbara S van der MeijDepartment of Nutrition, Dietetics and Lifestyle, School of Allied Health, HAN University of Applied Sciences, Nijmegen, the Netherlands; Department of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands.
Marian A E de van der SchuerenDepartment of Nutrition, Dietetics and Lifestyle, School of Allied Health, HAN University of Applied Sciences, Nijmegen, the Netherlands; Department of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands.

Funding

ZonMw 10430122210002
6 · The paper itself

Abstract

BACKGROUND/

aimsMalnutrition screening tools often include questions about unintentional weight loss (UWL). It is unclear whether individuals who intentionally desire to lose weight or perceive themselves as overweight interpret questions regarding UWL accurately. We assessed potential misclassification of UWL-related questions in these groups.

methodData from the Lifelines cohort was used (ñ125.000, age >18 years). Prevalence ratios (PRs) were calculated with a simple question regarding UWL as the dependent variable and the desire to lose weight and perception of one's body weight (too heavy vs. just right/too light) as separate independent variables. Associations were stratified by body mass index (BMI) group (normal weight vs. overweight/obesity) and adjusted for various comorbidities, demographics, and quality of life.

resultsOf participants with normal weight, 30.3 % desired to lose weight, 37.9 % perceived their body weight as too heavy and 5.1 % reported UWL; this was 80.1 %, 92.7 % and 2.7 % for those with overweight/obesity. In both BMI groups, the prevalence of UWL was ∼60 % lower in participants who desired to lose weight or perceived themselves as too heavy (prevalence ratios 0.40-0.43, p-value <0.05).

conclusionSince there is no logical basis for the desire to lose weight or one's perception of body weight to prevent UWL, lower reported prevalence rates on UWL-related questions are likely the result of misinterpretation. Malnutrition screening tools that include questions regarding UWL might underestimate the prevalence rates of malnutrition in higher BMIs, as individuals in these groups often aspire to lose weight or perceive themselves as too heavy.

Indexed as

MalnutritionWeight LossAdultAgedBody Mass IndexCohort StudiesFemaleHumansMaleMiddle AgedObesityOverweightPrevalenceQuality of LifeSurveys and QuestionnairesBody imageGLIMInvoluntary weight lossMisclassificationScreening tools

Identifiers

PMID40253812
PMCPMC7617719

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.