Evidence map›Paper›PMID 40253666›Full record

ArticleCell biochemistry and biophysics2025

Structural and Energetic Insights into the Binding of

Mahmoud A A Ibrahim, Dina E M Mohamed, Khlood A A Abdeljawaad, Alaa H M Abdelrahman, Shaban R M Sayed, Mohamed A El-Tayeb, Peter A Sidhom, Paul W Paré

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahmoud A A IbrahimComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt. m.ibrahim@compchem.net.
Dina E M MohamedComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Khlood A A AbdeljawaadComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Alaa H M AbdelrahmanComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, Egypt.
Shaban R M SayedDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, Saudi Arabia.
Mohamed A El-TayebDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh, Saudi Arabia.
Peter A SidhomDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Paul W ParéDepartment of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX, USA. paul.pare@ttu.edu.

Funding

King Saud University RSPD2025R678
6 · The paper itself

Abstract

Neuropilin-1 (NRP1) is a transmembrane glycoprotein that binds numerous ligands, including vascular endothelial growth factor A (VEGFA) that stimulates blood vessel formation. Preclinical trials propose that NRP1 inhibition blocks neoplasm cell proliferation and slows tumor growth by suppressing angiogenesis. As such, VEGFA/NRP1 signaling is a potential target for carcinoma inhibition. Since arginine (Arg) regulates nutrient-responsive rapamycin signaling, which in turn regulates cell growth and metabolism, Arg, as well as simple structural variations of

Indexed as

ArginineDensity Functional TheoryMolecular Docking SimulationMolecular Dynamics SimulationNeuropilin-1Binding SitesHumansLigandsProtein BindingThermodynamicsArginineLigandsNeuropilin-1DFT calculationsL- and D-Arginine analogsMolecular dockingMolecular dynamics simulationsNeuropilin 1 (NRP1)

Identifiers

PMID40253666

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.