Evidence map›Paper›PMID 40253647›Full record

ArticleJournal of aging and health2026

Telomere Length and Cognitive Function Among Middle-Aged and Older Participants From Communities Underrepresented in Aging Research: A Preliminary Study.

Lauren W Y McLester-Davis, Derek Norton, Ligia A Papale, Taryn T James, Hector Salazar, Sanjay Asthana, Sterling C Johnson, Diane C Gooding, Trevor R Roy, Reid S Alisch and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aging and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Lauren W Y McLester-DavisNative American Center for Health Professions, University of Wisconsin, Madison, WI, USA.ORCID 0000-0003-3504-5244
Derek NortonBiostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA.
Ligia A PapaleDepartment of Neurological Surgery, University of Wisconsin, Madison, WI, USA.
Taryn T JamesDepartment of Medicine, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-6843-8653
Hector SalazarSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Sanjay AsthanaDepartment of Medicine, University of Wisconsin, Madison, WI, USA.
Sterling C JohnsonDepartment of Psychology, University of Wisconsin, Madison, WI, USA.
Diane C GoodingDepartment of Medicine, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-0498-9472
Trevor R RoySchool of Medicine, Tulane University, New Orleans, LA, USA.
Reid S AlischDepartment of Neurological Surgery, University of Wisconsin, Madison, WI, USA.
Kirk J HoganDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Stacy S DruryDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
Carey E GleasonDepartment of Medicine, University of Wisconsin, Madison, WI, USA.
Megan ZuelsdorffSchool of Nursing, University of Wisconsin - Madison, Madison, WI, USA.

Funding

Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2019 to 2026
$34.5M
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPPELL, RICHARD J · 2009 to 2018
$16.2M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research NetworkU24AG066528 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI DRURY, STACY SCHMIDT · 2019 to 2023
$3.0M
Blood DNA Methylation Biomarkers of Alzheimer's DiseaseR01AG066179 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ALISCH, REID SPENCER, HOGAN, KIRK J · 2020 to 2024
$3.0M
Social-biological dimensions of ADRD risk and resilience in a Native American cohortR03AG063303 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ZUELSDORFF, MEGAN · 2019 to 2020
$310k
NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG054059NIA NIH HHS R01 AG066179NIA NIH HHS R03 AG063303NIA NIH HHS U24 AG066528
6 · The paper itself

Abstract

ObjectiveAccelerated biological aging is a plausible and modifiable determinant of dementia burden facing minoritized communities but is not well-studied in these historically underrepresented populations. Our objective was to preliminarily characterize relationships between telomere length and cognitive health among American Indian/Alaska Native (AI/AN) and Black/African American (B/AA) middle-aged and older adults.MethodsThis study included data on telomere length and neuropsychological test performance from 187 participants, enrolled in one of two community-based cognitive aging cohorts and who identified their primary race as AI/AN or B/AA.ResultsNested multivariable regression models revealed preliminary evidence for associations between telomere length and cognitive performance, and these associations were partially independent of chronological age.DiscussionSmall sample size limited estimate precision; however, findings suggest future work on telomere length and cognitive health in underrepresented populations at high risk for dementia is feasible and valuable as a foundation for social and behavioral intervention research.

Indexed as

AgingCognitionTelomereAgedAged, 80 and overBlack or African AmericanFemaleHumansMaleMiddle AgedNeuropsychological TestsWhiteAlzheimer’s diseasehealth disparitiesmolecular genetics biological agingrace and ethnicitytelomere length

Identifiers

PMID40253647
PMCPMC12590955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.