Evidence map›Paper›PMID 40253640›Full record

ArticlePlant biotechnology journal2025

CmFDa-mediated epigenetic regulation of flowering in chrysanthemum.

Wanjie Xue, Jiaxu Shi, Zhuozheng Li, Yumeng Zhang, Mingwei Tang, Xinyu Du, Zeyu An, Haowen Chen, Dian Yang, Xueqi Li and 6 more

Abstract read
In one paragraph

Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wanjie Xue *Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.ORCID https://orcid.org/0000-0003-0869-4062
Jiaxu Shi *Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.
Zhuozheng Li *Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.
Yumeng ZhangKey Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.
Mingwei TangCollege of Life Science, Northeast Forestry University, Harbin, China.
Xinyu DuCollege of Life Science, Northeast Forestry University, Harbin, China.
Zeyu AnKey Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.ORCID https://orcid.org/0000-0001-8776-9776
Haowen ChenCollege of Life Science, Northeast Forestry University, Harbin, China.
Dian YangCollege of Life Science, Northeast Forestry University, Harbin, China.
Xueqi LiKey Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.ORCID https://orcid.org/0000-0002-3369-5852
Fanqi BuKey Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.
Jialin XuCollege of Life Science, Northeast Forestry University, Harbin, China.
Yu WangKey Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.ORCID https://orcid.org/0000-0003-1753-0289
Qingzhu ZhangSchool of Ecology, Northeast Forestry University, Harbin, China.ORCID https://orcid.org/0000-0001-8246-6688
Yuhua LiKey Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.ORCID https://orcid.org/0000-0002-0405-2823
Yang ZhangKey Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.ORCID https://orcid.org/0000-0003-4132-9243

Funding

National Natural Science Foundation of China 32371932
6 · The paper itself

Abstract

FD, a conserved bZIP transcription factor, is well known for its role in promoting flowering. Here, we uncover that a short coding sequence of the Chrysanthemum morifolium FD gene, CmFDa, represses flowering. Interestingly, we identified CmFDa as a novel epiallele stringently regulated by DNA methylation in chrysanthemum for the first time. Epigenetic editing of the CmFDa promoter using the CRISPR-dCas9-TET1cd for demethylation or dCas9-SunTag-NtDRM2cd for methylation can, respectively, repress or promote flowering. CmFDa epigenetically represses the floral transition by suppressing the expression of the floral activators CmSOC1 and CmAP1. We show that CmFDa recruits the Polycomb-repressive complex 2 (PRC2) to the CmSOC1 and CmAP1 promoters. These results reveal that CmFDa is an inhibitor of flowering by epigenetic repression of flowering integrator genes. This study provides a novel strategy for the epigenetic improvement of flowering time in plants.

Indexed as

ChrysanthemumEpigenesis, GeneticFlowersPlant ProteinsDNA MethylationGene Expression Regulation, PlantPromoter Regions, GeneticPlant ProteinsDNA methylationepialleleFDfloweringH3K27me3polycomb‐repressive complex 2

Identifiers

PMID40253640
PMCPMC12205895

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.