Evidence map›Paper›PMID 40253585›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

In vivo programming of adult pericytes aids axon regeneration by providing cellular bridges for SCI repair.

Wenjing Sun, Elliot Dion, Fabio Laredo, Allyson Okonak, Jesse A Sepeda, Esraa Haykal, Min Zhou, Heithem M El-Hodiri, Andy J Fischer, Jerry Silver and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenjing SunDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Elliot DionDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Fabio LaredoDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA; University of Nottingham, Nottingham NG7 2QL, UK.
Allyson OkonakDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Jesse A SepedaDepartment of Neurology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Esraa HaykalDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Min ZhouDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Heithem M El-HodiriDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Andy J FischerDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA.
Jerry SilverDepartment of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Juan PengCenter for Biostatistics and Bioinformatics, The Ohio State University, Columbus, OH 43210, USA.
Andrew SasDepartment of Neurology, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA; Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA.
Andrea TedeschiDepartment of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA; Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA. Electronic address: andrea.tedeschi@osumc.edu.

Funding

Arginase positive monocyte mediated RGC neuroprotection after traumatic optic neuropathyR01EY035307 · NEI · OHIO STATE UNIVERSITY · PI Andrew Robert Sas · 2024 to 2026
$1.3M
NEI NIH HHS R01 EY035307
6 · The paper itself

Abstract

Pericytes are contractile cells of the microcirculation that participate in wound healing after spinal cord injury (SCI). Thus far, the extent to which pericytes cause or contribute to axon growth and regeneration failure after SCI remains controversial. Here, we found that SCI leads to profound changes in vasculature architecture and pericyte coverage. We demonstrated that pericytes constrain sensory axons on their surface, causing detrimental structural and functional changes in adult dorsal root ganglion neurons that contribute to axon regeneration failure after SCI. Perhaps more excitingly, we discovered that in vivo programming of adult pericytes via local administration of platelet-derived growth factor BB (PDGF-BB) effectively promotes axon regeneration and recovery of hindlimb function by contributing to the formation of cellular bridges that span the lesion. Ultrastructural analysis showed that PDGF-BB induced fibronectin fibril alignment and extension, effectively converting adult pericytes into a permissive substrate for axon growth. In addition, PDGF-BB localized delivery positively affects the physical and chemical nature of the lesion environment, thereby creating more favorable conditions for SCI repair. Thus, therapeutic manipulation rather than wholesale ablation of pericytes can be exploited to prime axon regeneration and SCI repair.

Indexed as

AxonsNerve RegenerationPericytesSpinal Cord InjuriesAnimalsBecaplerminDisease Models, AnimalGanglia, SpinalHumansMiceProto-Oncogene Proteins c-sisRecovery of FunctionBecaplerminProto-Oncogene Proteins c-sisaxon regenerationDRG neuronsextracellular matrixfunctional recoveryPDGF-BBpericytesspinal cord injuryvasculature remodeling

Identifiers

PMID40253585
PMCPMC12461639

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.