ArticleDiscover oncology2025
Single-cell RNA sequencing reveals key signaling pathways and biological functions in giant cell tumors of bone.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- NMR-based metabolomics in a clinical cohort: deciphering the metabolic characteristics of gout with the dampness-heat syndrome and elucidate the efficacy of Simiao Pill.Chinese medicine · 2026Article
- Alternative Splicing: A Critical Regulator in Human Bone Biology and Tumor Progression.Research (Washington, D.C.) · 2025Review
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Authors and funding
2 authors.
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Abstract
backgroundGiant cell tumor of bone (GCTB) represents a group of tumors that characterized by their heterogeneity and the presence of multiple cell types. It is essential to understand their molecular mechanisms for better designing therapeutic approaches.
methodsWe applied single cell RNA-sequencing technology to investigate differentiation process during GCTBs formation. DAVID was used to perform a pathway enrichment and Gene Ontology (GO) analyses on signaling pathways and biological functions. Cell-cell interactions and signaling networks are depicted with network diagrams and usages of heatmaps.
resultsThe analysis identified numerous significant pathways, including Pathways in Parkinson's disease, Prion diseases and COVID-19. ViBe identified a wide range of biological process, cellular component and molecular function associated with tumorigenesis. Furthermore, we validate that the SPP1 signaling pathway is essential for cell-cell crosstalk, specifically functioning as a positive feedback loop between cancer-associated fibroblasts and macrophages.
conclusionOur study revealed comprehensive molecular and intercellular interaction networks in GCTB, which may advance the understanding of the pathogenic mechanisms in GCTB and contribute essential information for its treatment. Our findings make confution in the complex functional dynamics in the TME.
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