Evidence map›Paper›PMID 40253573›Full record

ArticleAnnals of nuclear medicine2025

Elapsed time changes of the brain radiopharmaceutical accumulation of the amyloid PET examination using

Shota Takemoto, Koji Onuki, Keiko Tanimoto, Masaho Taniguchi, Takako Suero, Mio Okamoto, Satoshi Kimura, Monami Osawa, Haruka Takeshige-Amano, Noriko Nishikawa and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shota TakemotoDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan. stakemot@juntendo.ac.jp.ORCID http://orcid.org/0009-0004-3291-8809
Koji OnukiDepartment of Radiology, Juntendo Tokyo Koto Geriatric Medical Center, 3‑3‑20, Shinsuna, Koto‑ku, Tokyo, 136‑0075, Japan.
Keiko TanimotoDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Masaho TaniguchiDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Takako SueroDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Mio OkamotoDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Satoshi KimuraDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Monami OsawaDepartment of Neurology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Haruka Takeshige-AmanoDepartment of Neurology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Noriko NishikawaDepartment of Neurology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Shigeki AokiDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Ryohei KuwatsuruDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.
Koji MurakamiDepartment of Radiology, Juntendo University Hospital, 3‑1‑3, Hongo, Bunkyo‑ku, Tokyo, 113‑8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study was to examine how the radiopharmaceutical accumulation in the brain changes with the elapsed time between the administration of

methodsThe study population consisted of 25 subjects who agreed to participate in the study. After visual evaluation by the radiologist, 14 subjects tested negative for Aβ accumulation, and 11 subjects tested positive as well. The study population was treated with

resultsIn most of the PET images, pixel values showed a decreasing trend with elapsed time after radiopharmaceutical administration. Accordingly, calculated SUVr and Centiloid Scale also changed.

conclusionsElapsed time after radiopharmaceutical administration resulted in a washout of the radiopharmaceutical accumulation in the brain. From this, it was suggested that the quantitative indices change.

Indexed as

Aniline CompoundsBenzothiazolesBrainPositron-Emission TomographyRadiopharmaceuticalsAdultAgedFemaleHumansMaleMiddle AgedTime FactorsAniline CompoundsBenzothiazolesflutemetamolRadiopharmaceuticals18F-flutemetamolAmyloidBrainCentiloid scalePETSUVr

Identifiers

PMID40253573
PMCPMC12174224

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.