Evidence map›Paper›PMID 40253525›Full record

ArticleScientific reports2025

Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer.

Jibira Yakubu, Evangelos Natsaridis, Therina du Toit, Isabel Sousa Barata, Oya Tagit, Amit V Pandey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jibira YakubuPediatric Endocrinology, University Children's Hospital, University Hospital Bern, Inselspital, Freiburgstrasse 15, KIKL C837, 3010, Bern, Switzerland.
Evangelos NatsaridisGroup of Biointerfaces, Institute of Chemistry and Bioanalytics, FHNW University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.
Therina du ToitTranslational Hormone Research Program, Department of Biomedical Research, Faculty of Medicine, University of Bern, Bern, Switzerland.
Isabel Sousa BarataPediatric Endocrinology, University Children's Hospital, University Hospital Bern, Inselspital, Freiburgstrasse 15, KIKL C837, 3010, Bern, Switzerland.
Oya TagitGroup of Biointerfaces, Institute of Chemistry and Bioanalytics, FHNW University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.
Amit V PandeyPediatric Endocrinology, University Children's Hospital, University Hospital Bern, Inselspital, Freiburgstrasse 15, KIKL C837, 3010, Bern, Switzerland. amit.pandey@unibe.ch.

Funding

CANCER RESEARCH SWITZERLAND KFS-5557-02-2022Marie Skłodowska-Curie Individual Fellowship 101023999SWISS GOVERNMENT EXCELLENCE SCHOLARSHIP (ESKAS) 2022.0470SWISS GOVERNMENT EXCELLENCE SCHOLARSHIP (ESKAS) 2023.0011UniBern Forschungsstiftung 2024_37
6 · The paper itself

Abstract

Endogenous androgens are pivotal in the development and progression of prostate cancer (PC). We investigated nanoparticle formulations of curcumin and piperine in modulating steroidogenesis within PC cells. Using multiple PC cell lines (LNCaP, VCaP, DU145 and PC3) we studied the effects of curcumin, piperine, and their nanoparticle formulations-curcumin nanoparticles, piperine nanoparticles, and curcumin-piperine nanoparticles (CPN)-on cell viability, migration, and steroid biosynthesis. Curcumin and its nanoparticle formulations significantly reduced cell viability in PC cells, with curcumin-piperine nanoparticles showing the highest efficacy. These treatments also inhibited cell migration, with CPN exhibiting the most pronounced effect. In assays for steroid biosynthesis, curcumin, and its nanoparticle formulations, as well as piperine and its nanoparticles, selectively inhibited 17α-hydroxylase and 17,20-lyase activities of cytochrome P450 17A1 (CYP17A1). Abiraterone, a CYP17A1 inhibitor, displayed a broader inhibition of steroid metabolism including cytochrome P450 21-hydroxylase activity, whereas curcumin and piperine provided a more targeted inhibition profile. Analysis of steroid metabolites by liquid chromatography-mass spectrometry revealed that CPN caused significant reduction of androstenedione and cortisol, suggesting potential synergistic effects. In conclusion, nanoformulations co-loaded with curcumin and piperine offer an effective approach to targeting steroidogenesis and could be promising candidates for therapies aimed at managing androgen-dependent PC.

Indexed as

CurcuminCytochrome P-450 Enzyme InhibitorsNanoparticle Drug Delivery SystemProstatic NeoplasmsSteroid 17-alpha-HydroxylaseAdrenal GlandsAlkaloidsBenzodioxolesCaco-2 CellsCell CycleCurcumaCytochromes b5Drug Screening Assays, AntitumorGene ExpressionHumansNanoparticlesAlkaloidsBenzodioxolesCurcuminCYB5A protein, humanCYP17A1 protein, humanCytochrome P-450 Enzyme InhibitorsCytochromes b5Nanoparticle Drug Delivery SystemPhytochemicalsPiperidinespiperinePlant ExtractsPolyunsaturated AlkamidesSteroid 17-alpha-HydroxylaseSteroidsAndrogen synthesisCurcumin nanoparticlesCYP17A1Nanoparticle formulationsProstate cancerSteroidogenesis

Identifiers

PMID40253525
PMCPMC12009323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.