ArticleNature communications2025
Exploring and expanding the natural chemical space of bacterial diterpenes.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Chemoenzymatic Synthesis of (4R,7R)-Zingiberene Enables Construction of nor-Sesquiterpene Semiochemical Analogs.Chembiochem : a European journal of chemical biology · 2026Article
- Discovery and Biosynthetic Characterization of Darumycins Expand the Chemical Space of Sesterterpene Antibiotics.JACS Au · 2026Article
- Sequence-guided engineering of a bacterial diterpene synthase induces further cyclization.ACS catalysis · 2026Article
- Diverse biosynthetic pathways in Arctic hydrothermal biofilms.Nature communications · 2026Article
- Article
- Synthesis of N-Acetyl-D- and -L-Leucine-ChemMedChem · 2026Article
- Development of Potent and Cell Active 5-Azaindole-Based Tau Tubulin Kinase Inhibitors.bioRxiv : the preprint server for biology · 2026Article
- Biosynthetic formation of the 6/7/5-odyverdiene diterpenes via a 6/10-ACS catalysis · 2026Article
- A Single Residue Switch Controls Isomer Selectivity in the Myxobacterial Isobonnadiene Synthase.Organic letters · 2026Article
- Integrated characterization of six sesquiterpene synthases unravels diversified terpene biosynthesis in the mint speciesFrontiers in plant science · 2026Article
- Pathogenic Characteristics and Molecular Epidemiological Analysis ofInfection and drug resistance · 2026Article
- Biodiversity-Driven Natural Products and Bioactive Metabolites.Plants (Basel, Switzerland) · 2025Review
- Mechanistic Characterisation of Bacterial Terpene Synthases from Chitinophagaceae Producing Marine-Type Diterpenes.Angewandte Chemie (International ed. in English) · 2025Article
- Mechanistic Characterisation of a Diterpene Synthase for Chryseojoostenes A-E from Chryseobacterium Joostei.Angewandte Chemie (International ed. in English) · 2025Article
- Discovery of UbiA-Type Cyathane Synthases in Bacteria.ACS catalysis · 2025Article
- The initial dynamics of product release in terpene synthases-The case of CotB2.Protein science : a publication of the Protein Society · 2025Article
- Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria.Angewandte Chemie (International ed. in English) · 2025Article
- Genome Mining of Terpene Synthases from FourteenMicroorganisms · 2025Article
- Avoidance of Secondary Carbocations, Unusual Deprotonation, and Nonstatistical Dynamic Effects in the Cyclization Mechanism of Tetraisoquinane.Journal of the American Chemical Society · 2025Article
- Comprehensive Genome Analysis of a Human-Derived β-Lactam-ResistantInfection and drug resistance · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
Terpenoids are the largest family of natural products but relatively rare in bacteria. Genome mining reveals widespread prevalence of terpene synthases, the enzymes responsible for constructing the hydrocarbon skeletons, in bacteria. Here, we show that 125 (37%) of 334 terpene synthases from 8 phyla, 17 classes, and 83 genera of bacteria are active as diterpene synthases. Isolation and structural elucidation of 28 diterpenes from 31 terpene synthases reveal three previously unreported terpene skeletons, skeletons of natural products from other organisms with unknown biosynthetic pathways, diterpenes that are known in other organisms but to the best of our knowledge not previously seen in bacteria, or new structural and stereochemical isomers of diterpenes. We also identify type I diterpene synthases from myxobacteria and cyanobacteria. This study will help to discover new natural products, advance studies in terpenoid biosynthesis and enzymology, and provide model systems to probe the ecological roles of terpenes.
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