Evidence map›Paper›PMID 40253369›Full record

ArticleVirology journal2025

Characteristics of molecular epidemiology and transmitted drug resistance among newly diagnosed HIV-1 infections in Lishui, China from 2020 to 2023.

Jinkai Li, Jianhua Mei, Jie Yu, Xiaolei Chen, Jianliang Zhu, Jiaji Ye, Deyong Zhang, Dongqing Cheng, Xiuying Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinkai Li *School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Jianhua Mei *Lishui Center for Disease Control and Prevention, Lishui, 323000, China.
Jie YuLishui Center for Disease Control and Prevention, Lishui, 323000, China.
Xiaolei ChenLishui Center for Disease Control and Prevention, Lishui, 323000, China.
Jianliang ZhuLishui Center for Disease Control and Prevention, Lishui, 323000, China.
Jiaji YeSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Deyong ZhangLishui Center for Disease Control and Prevention, Lishui, 323000, China. cdc2211533@126.com.
Dongqing ChengSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, 310053, China. chengdq@zcmu.edu.cn.
Xiuying ChenLishui Center for Disease Control and Prevention, Lishui, 323000, China. lscdccxy@163.com.

Funding

Lishui Science and Technology Project 2023GYX17, 2024GYX46
6 · The paper itself

Abstract

backgroundTransmitted drug resistance (TDR) is becoming an obstacle to the success of antiretroviral therapy (ART) as the HIV epidemic continues to spread. This study aimed to investigate the characteristics of TDR and the molecular epidemiology of ART-naive HIV-1 infections in Lishui.

methodsA total of 481 plasma samples were collected from ART-naive HIV-1 infections in Lishui between 2020 and 2023. The sequences acquired from infections were used to analyze the characteristics of genotype, TDR, and molecular transmission network.

resultsThis study discovered that the three most prevalent subtypes among the 455 sequences successfully obtained from infections in Lishui were CRF08_BC (35.8%), CRF07_BC (26.4%), and CRF01_AE (25.9%). The overall prevalence of TDR was 12.1%, and the K103N (2.4%) was the most frequent mutation. Multivariate analysis showed that CRF08_BC (OR = 5.401, P < 0.001) and CD4

conclusionsThis study revealed that the prevalence of TDR was at an intermediate level of drug resistance, and high levels of resistance were predominantly concentrated in efavirenz (EFV) and nevirapine (NVP) among the NNRTIs. Middle-aged and older infections represented a significant proportion of the molecular transmission network. This suggests that HIV surveillance and targeted prevention and treatment interventions are essential to reduce the risk of HIV transmission.

Indexed as

Drug Resistance, ViralHIV-1HIV InfectionsAdolescentAdultAnti-HIV AgentsChinaFemaleGenotypeHumansMaleMiddle AgedMolecular EpidemiologyMutationPrevalenceYoung AdultAnti-HIV AgentsHIV-1Molecular epidemiologyTransmission networkTransmitted drug resistance

Identifiers

PMID40253369
PMCPMC12008846

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.