Evidence map›Paper›PMID 40253364›Full record

ArticleVeterinary research2025

The effect of asparagine-13 in porcine epidemic diarrhea virus envelope protein on pathogenicity.

Zhiwei Li, Zhiqian Ma, Xiaojing Zhao, Yongqi Li, Congsen Zheng, Yang Li, Xuyang Guo, Lele Xu, Zifang Zheng, Haixue Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiwei Li *State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Zhiqian Ma *State Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Xiaojing ZhaoState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Yongqi LiState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Congsen ZhengState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Yang LiState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Xuyang GuoState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Lele XuState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Zifang ZhengState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Haixue ZhengState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Shuqi XiaoState Key Laboratory for Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, College of Veterinary Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China. shqxiaojd@126.com.ORCID http://orcid.org/0000-0002-6468-2608

Funding

China Agriculture Research System of Ministry CARS-35China Postdoctoral Science Foundation 2024M753579Joint Research Foundation of Gansu Province 23JRRA1476Joint Research Foundation of Gansu Province 23JRRA1480National Natural Science Foundation of China 32402888
6 · The paper itself

Abstract

The pathogenesis of porcine epidemic diarrhea virus (PEDV) has not been fully clarified, which seriously hinders the prevention of the disease. The envelope (E) protein of PEDV induces the expression of pro-inflammatory cytokines, but the role of these inflammatory reactions in PEDV pathogenicity is still unknown. In this study, the asparagine at position 13 was found to be crucial to PEDV E protein induced inflammatory response. Exogenously expressing the parent E protein, rather than the E mutant carrying N13A, induces the activation of NF-κB and expression of inflammatory factors, including IL-6, IL-8, and TNF-α. Compared with the parental rPEDV strain, the recombinant strain rPEDV-E

Indexed as

AsparagineCoronavirus InfectionsPorcine epidemic diarrhea virusSwine DiseasesViral Envelope ProteinsAnimalsSwineVirulenceAsparagineViral Envelope Proteinsenvelope proteinPorcine epidemic diarrhea viruspro-inflammatory cytokinesreverse genetic systemvirulence factor

Identifiers

PMID40253364
PMCPMC12008953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.