Evidence map›Paper›PMID 40253334›Full record

ReviewJournal of neuroengineering and rehabilitation2025

Closed-loop rehabilitation of upper-limb dyskinesia after stroke: from natural motion to neuronal microfluidics.

Honggang Wang, Junlong Guo, Yangqi Zhang, Ze Fu, Yufeng Yao

Abstract readReview
In one paragraph

Review in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Honggang WangState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China.
Junlong GuoState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China.
Yangqi ZhangState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China.
Ze FuInstitute of Biological and Medical Technology, Harbin Institute of Technology (Weihai), Weihai, 264200, China.
Yufeng YaoState Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China. yufeng.yao@hit.edu.cn.

Funding

Central Guided Local Science and Technology Development Funds Project, Basic Research Project 206Z0301GHigh-end medical device innovation community funding in Shandong Province 2022-SGTTXM-017National Natural Science Foundation of China 91648106Tianzhi Institute of Innovation and Technology TZ-ZZ-202002
6 · The paper itself

Abstract

This review proposes an innovative closed-loop rehabilitation strategy that integrates multiple subdomains of stroke science to address the global challenge of upper-limb dyskinesia post-stroke. Despite advancements in neural remodeling and rehabilitation research, the compartmentalization of subdomains has limited the effectiveness of current rehabilitation strategies. Our approach unites key areas-including the post-stroke brain, upper-limb rehabilitation robotics, motion sensing, metrics, neural microfluidics, and neuroelectronics-into a cohesive framework designed to enhance upper-limb motion rehabilitation outcomes. By leveraging cutting-edge technologies such as lightweight rehabilitation robotics, advanced motion sensing, and neural microfluidic models, this strategy enables real-time monitoring, adaptive interventions, and personalized rehabilitation plans. Furthermore, we explore the potential of closed-loop systems to drive neural plasticity and functional recovery, offering a transformative perspective on stroke rehabilitation. Finally, we discuss future directions, emphasizing the integration of emerging technologies and interdisciplinary collaboration to advance the field. This review highlights the promise of closed-loop strategies in achieving unprecedented integration of subdomains and improving post-stroke upper-limb rehabilitation outcomes.

Indexed as

DyskinesiasMicrofluidicsStroke RehabilitationUpper ExtremityHumansRecovery of FunctionRoboticsStrokeDyskinesiaElectrophysiologyMicrofluidicsNeurorehabilitationRehabilitationSensing and metricsStroke

Identifiers

PMID40253334
PMCPMC12008995

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.