Evidence map›Paper›PMID 40252970›Full record

ArticleThe American journal of pathology2025

A Disintegrin and Metalloproteinase 10 Regulates Ephrin B2-Mediated Endothelial Cell Sprouting and Ischemic Retinopathy.

Shivantika Bisen, Purnima Gogoi, Anamika Sharma, Chandra S Mukhopadhyay, Nikhlesh K Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Infection and immunity · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shivantika BisenIntegrative Biosciences Center, Wayne State University, Detroit, Michigan; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, Michigan.
Purnima GogoiIntegrative Biosciences Center, Wayne State University, Detroit, Michigan; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, Michigan; Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin.
Anamika SharmaIntegrative Biosciences Center, Wayne State University, Detroit, Michigan; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, Michigan.
Chandra S MukhopadhyayDepartment of Bioinformatics, College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India.
Nikhlesh K SinghIntegrative Biosciences Center, Wayne State University, Detroit, Michigan; Department of Ophthalmology, Visual and Anatomical Sciences, School of Medicine, Wayne State University, Detroit, Michigan. Electronic address: nsingh2@wayne.edu.

Funding

VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
CELLULAR MECHANISMS OF PATHOLOGICAL RETINAL NEOVASCULARIZATIONR01EY029709 · NEI · WAYNE STATE UNIVERSITY · PI SINGH, NIKHLESH KUMAR · 2019 to 2023
$1.9M
NEI NIH HHS P30 EY004068NEI NIH HHS R01 EY029709
6 · The paper itself

Abstract

Retinal neovascularization is the leading cause of visual impairment in diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration. The extracellular matrix breakdown by metalloproteinase leads to vascular complications in various proliferative retinopathies. A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) is involved in physiological angiogenesis. However, limited information exists regarding the role of ADAM10 in proliferative retinopathies. In this study, the levels of active ADAM10 were significantly up-regulated in the ischemic retina, and down-regulation or inactivation of ADAM10 significantly inhibited the proliferation, sprouting, migration, and tube formation of human retinal microvascular endothelial cell. Furthermore, the endothelial cell (EC)-specific deletion of ADAM10 (ADAM10

Indexed as

ADAM10 ProteinAmyloid Precursor Protein SecretasesEndothelial CellsIschemiaMembrane ProteinsRetinal NeovascularizationAnimalsCell MovementCell ProliferationEphrin-B2HumansMiceMice, Inbred C57BLRetinaRetinal VesselsADAM10 ProteinADAM10 protein, humanAdam10 protein, mouseAmyloid Precursor Protein SecretasesEFNB2 protein, humanEphrin-B2Membrane Proteins

Identifiers

PMID40252970
PMCPMC12264544

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.