Evidence map›Paper›PMID 40252877›Full record

ArticleNeuroImage2025

Spatiotemporal processing of real faces is modified by visual sensing.

Megan Kelley, Mark Tiede, Xian Zhang, J Adam Noah, Joy Hirsch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Megan KelleyInterdepartmental Neuroscience Program, Yale Graduate School of Arts and Sciences, New Haven 06511, CT, USA; Brain Function Laboratory, Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 902, New Haven, CT, USA.
Mark TiedeBrain Function Laboratory, Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 902, New Haven, CT, USA.
Xian ZhangBrain Function Laboratory, Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 902, New Haven, CT, USA.
J Adam NoahBrain Function Laboratory, Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 902, New Haven, CT, USA.
Joy HirschBrain Function Laboratory, Department of Psychiatry, Yale School of Medicine, 300 George St., Suite 902, New Haven, CT, USA; Wu Tsai Institute, Yale University New Haven 06511, CT, USA; Center for Brain & Mind Health, Yale School of Medicine, New Haven 06511, CT, USA; Department of Neuroscience, Yale School of Medicine, New Haven 06511, CT, USA; Department of Comparative Medicine, Yale School of Medicine, New Haven 06511, CT, USA; Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK. Electronic address: joy.hirsch@yale.edu.

Funding

Neural Mechanisms for Social Interactions and Eye Contact in ASDR01MH111629 · NIMH · YALE UNIVERSITY · PI HIRSCH, JOY, MCPARTLAND, JAMES CHARLES · 2016 to 2020
$3.2M
Mechanisms of Interpersonal Social Communication: Dual-Brain fNIRS InvestigationR01MH107513 · NIMH · YALE UNIVERSITY · PI HIRSCH, JOY · 2015 to 2019
$2.1M
Mechanisms of Dynamic Neural Coupling during Face-to-Face Expressions of EmotionR01MH119430 · NIMH · YALE UNIVERSITY · PI HIRSCH, JOY · 2019 to 2023
$2.0M
Basic neural processing mechanisms of live human face viewingK00MH139095 · NIMH · YALE UNIVERSITY · PI Megan Kelley · 2024 to 2026
$258k
Basic neural processing mechanisms of live human face viewingF99NS129174 · NINDS · YALE UNIVERSITY · PI KELLEY, MEGAN · 2022 to 2022
$33k
NIMH NIH HHS K00 MH139095NIMH NIH HHS R01 MH107513NIMH NIH HHS R01 MH111629NIMH NIH HHS R01 MH119430NINDS NIH HHS F99 NS129174
6 · The paper itself

Abstract

Live human faces, when engaged as visual stimuli, recruit unique and extensive patterns of neural activity. However, the underlying neural mechanisms that underly these live face-to-face processes are not known. We hypothesized that the neural correlates for live face processes are modulated by both spatial and temporal features of the live faces as well as visual sensing parameters. Hemodynamic signals detected by functional near infrared spectroscopy (fNIRS) were acquired concurrently with co-activated electroencephalographic (EEG) and eye-tracking signals during interactive gaze at a live human face or gaze at a human-like robot face. Regression of the fNIRS signals with two eye-gaze variables, fixation duration and dwell time, revealed separate regions of neural correlates, right supramarginal gyrus (lateral visual stream) and right inferior parietal sulcus (dorsal visual stream), respectively. These two areas served as the regions of interest for the EEG analysis. Standardized low-resolution brain electromagnetic tomography (sLORETA) was applied to determine theta (4 - 7 Hz) and alpha (8-13 Hz) oscillatory activity in these regions. Variations in oscillatory patterns corresponding to the neural correlates of the visual sensing parameters suggest an increase in spatial binding for the dorsal relative to the lateral regions of interest during live face-to-face visual stimulation.

Indexed as

Facial RecognitionAdultBrain MappingElectroencephalographyEye-Tracking TechnologyFemaleHumansMaleSpectroscopy, Near-InfraredYoung AdultBinding mechanismsDorsal parietal cortexfNIRSFunctional near infrared spectroscopyInteractive social neuroscienceSimultaneous EEG and fNIRSSupramarginal gyrusVisual sensing

Identifiers

PMID40252877
PMCPMC12140127

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.