ArticleJournal of thrombosis and haemostasis : JTH2025
Clonal hematopoiesis of indeterminate potential and incidence of venous thromboembolism in older adults.
Article in Journal of thrombosis and haemostasis : JTH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical management of clonal hematopoiesis.Cancer · 2026Review
- An Italian cartography of VEXAS-related thrombosis.HemaSphere · 2026Article
- Clonal Hematopoiesis of Indeterminate Potential (CHIP): A Model of Mutation-Driven Thromboinflammation.Cancers · 2026Review
- Counting the CHIPs: The High-Stakes Role of Clonal Hematopoiesis in Multiple Myeloma.Biomedicines · 2026Review
- Mutation-specific impairment of TET2 and DNMT3A enzymatic activity predicts clonal hematopoiesis disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms.Journal of clinical medicine · 2026Review
- Clonal Hematopoiesis (CHIP) in Pulmonary Embolism and CTEPH: Evidence, Mechanisms, and Risk Stratification.International journal of molecular sciences · 2026Review
- Target practice: Opportunities for therapeutic intervention in CHIP and CCUS.Blood reviews · 2025Review
- Unravelling the role of TET2 in venous thromboembolism: insights into mechanisms and therapeutic implications.Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundClonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases, but its association with venous thromboembolic events (VTE) is unclear.
objectivesWe investigated the association between CHIP and incident VTE in older adults and evaluated whether risk varies by CHIP driver gene.
methodsParticipants from the community-based Atherosclerosis Risk in Communities Study without a history of VTE or hematologic malignancies were included. Whole-exome sequencing from peripheral blood was used to ascertain CHIP (variant allele frequency ≥ 2%) and common gene-specific CHIP subtypes (DNMT3A, TET2, and ASXL1). The primary outcome was incident VTE (adjudicated by experts from medical record review), defined as symptomatic and asymptomatic pulmonary embolism and lower extremity deep vein thrombosis. Multivariable Cox proportional hazard models were used to study the association between CHIP and VTE.
resultsOf 3980 participants included (median [25th-75th percentiles] age, 75.0 [71.0-79.0] years), 2359 (59.3%) were female, 1621 (40.7%) were male, 890 (22.4%) identified as Black, and 3090 (77.6%) identified as White; 985 (24.7%) had CHIP. Over a median 7.1-year follow-up, VTE occurred in 44 (4.5%) CHIP carriers vs 96 (3.2%) noncarriers (hazard ratio, 1.49; 95% CI, 1.02-2.17; P = .038). TET2 mutation was significantly associated with VTE risk (hazard ratio, 2.25; 95% CI, 1.27-4.00; P = .006).
conclusionIn this cohort study of older adults, we identified a modestly increased risk of VTE in individuals with CHIP, mainly driven by TET2 mutation. Future research should explore the mechanisms driving these associations and assess potential therapeutic and preventive strategies.
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