Evidence map›Paper›PMID 40252827›Full record

ArticleJournal of advanced research2026

Design, synthesis and activity evaluation of dual-target inhibitors against papain-like and main proteases of porcine epidemic diarrhea virus.

Jiashu Chen, Yuxi Lin, Chenxia Gao, Zhuoya Wang, Yue Xu, Yuanyuan Zhao, Chao Xie, Chao Liu, Nan Zhou, Wenlong Shan and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jiashu ChenState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Yuxi LinState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Chenxia GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Zhuoya WangGOSCI Technology Group, Qingdao 266237 Shandong, PR China.
Yue XuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Yuanyuan ZhaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Chao XieState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Chao LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Nan ZhouState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Wenlong ShanState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Wenli ZhuangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Hongyun QinState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Cong ShiState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Ruihua LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Zemin WangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Pan XingState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China.
Jiqiang ZhuLead High Technology (QingDao) Co., Ltd., Qingdao 266237 Shandong, PR China.
Bokan WangShandong Lead High Biotechnology Co., Ltd., Jinan 250031 Shandong, PR China.
Xiangqian LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China. Electronic address: lixiangqian@sdu.edu.cn.
Dayong ShiState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237 Shandong, PR China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237 Shandong, PR China. Electronic address: shidayong@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPorcine epidemic diarrhea (PED), caused by porcine epidemic diarrhea virus (PEDV), threatens the global pig industry due to lack of drugs. PEDV replication relies on PL

objectivesA series of dual-targeted inhibitors of M

methodsDual-targeted inhibitors of M

resultsAmong the sixty-four synthesized compounds, seventeen potent dual-targeted inhibitors of PL

conclusionsIn summary, a potent dual-targeted inhibitor of PL

Indexed as

Antiviral AgentsCoronavirus InfectionsCoronavirus Papain-Like ProteasesPorcine epidemic diarrhea virusProtease InhibitorsAnimalsAnti-Inflammatory AgentsChlorocebus aethiopsDrug DesignMiceSwineSwine DiseasesVero CellsVirus ReplicationAnti-Inflammatory AgentsAntiviral AgentsCoronavirus Papain-Like ProteasesProtease InhibitorsAnti-inflammatoryDual-target inhibitorsM(pro)PEDVPL(pro)

Identifiers

PMID40252827
PMCPMC12869208

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.