Evidence map›Paper›PMID 40252642›Full record

ArticleCell reports. Medicine2025

Myeloperoxidase impacts vascular function by altering perivascular adipocytes' secretome and phenotype in obesity.

Alexander Hof, Max Landerer, Philipp Peitsmeyer, Ronja Herzog, Jens Alber, Maysam Ahdab, Felix Sebastian Nettersheim, Dennis Mehrkens, Simon Geißen, Simon Braumann and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Alexander HofHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Max LandererHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Philipp PeitsmeyerDepartment of Cardiology, University Heart and Vascular Center Hamburg, 2024 Hamburg, Germany.
Ronja HerzogDepartment of Cardiology, University Heart and Vascular Center Hamburg, 2024 Hamburg, Germany.
Jens AlberMax Planck Institute for Metabolism Research, 50937 Cologne, Germany.
Maysam AhdabHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Felix Sebastian NettersheimHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Dennis MehrkensHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Simon GeißenHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Simon BraumannHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Henning GuthoffHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Philipp von SteinHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Harshal NemadeHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Felix Simon Ruben PicardHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.
Ramona BraunMax Planck Institute for Metabolism Research, 50937 Cologne, Germany.
Friedrich Felix HoyerHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Jens Claus BrüningMax Planck Institute for Metabolism Research, 50937 Cologne, Germany.
Alexander PfeiferInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
Staffan HildebrandInstitute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
Holger WinkelsHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Stephan BaldusHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Matti AdamHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Jasper SchäkelHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.
Martin MollenhauerHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany. Electronic address: martin.mollenhauer@uk-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity, a main driver of cardiovascular morbidity, contributes to endothelial dysfunction and inflammation in adipose tissues. Perivascular adipose tissue (PVAT) surrounds arteries and influences vascular function. In obesity, immune cells, including myeloperoxidase (MPO)-releasing myeloid cells, accumulate in PVAT. In this study, we show MPO levels to correlate with body weight and endothelial function in obese patients (n = 33) and mice. In addition, MPO deficiency reduces immune cell frequency, enhances PVAT beiging via soluble guanylyl cyclase β1 (sGC-β1), and increases oxygen consumption in vivo. Further, nitrotyrosine formation and inflammatory cytokine release are attenuated in obese Mpo

Indexed as

AdipocytesObesityPeroxidaseSecretomeAdiponectinAdipose TissueAdultAnimalsFemaleHumansInflammationMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedAdiponectinPeroxidaseadiponectinendothelial functioninflammationmyeloperoxidaseobesityperivascular adipose tissue

Identifiers

PMID40252642
PMCPMC12147848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.