Evidence map›Paper›PMID 40252498›Full record

ArticleEuropean journal of cell biology2025

Viral vaccines promote endoplasmic reticulum stress-induced unfolding protein response in teleost erythrocytes.

Maria Salvador-Mira, Paula Gimenez-Moya, Alba Manso-Aznar, Ester Sánchez-Córdoba, Manuel A Sevilla-Diez, Veronica Chico, Ivan Nombela, Sara Puente-Marin, Nerea Roher, Luis Perez and 4 more

Erratum issuedAbstract read
In one paragraph

Article in European journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Maria Salvador-MiraInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Paula Gimenez-MoyaInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Alba Manso-AznarInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Ester Sánchez-CórdobaInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Manuel A Sevilla-DiezInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Veronica ChicoInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Ivan NombelaInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Sara Puente-MarinInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Nerea RoherInstitute of Biotechnology and Biomedicine (IBB) & Department of Cellular Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Barcelona, Spain.
Luis PerezInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain.
Tanja DučićALBA Synchrotron Light Source, Cerdanyola del Vallès, Barcelona, Spain.
Núria Benseny-CasesDepartment of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, Barcelona, Spain.
Ana Joaquina Perez-BernaALBA Synchrotron Light Source, Cerdanyola del Vallès, Barcelona, Spain.
Maria Del Mar Ortega-VillaizanInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernández (IDiBE-UMH), Elche, Spain. Electronic address: mortega-villaizan@umh.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most available evidence points to a proviral role for endoplasmic reticulum (ER) stress, as many viruses exploit it to promote viral replication. In contrast, few studies have linked ER stress to the antiviral immune response, and even fewer to the vaccine-induced immune response. In this work, we demonstrated that ER stress is a key molecular link in the immune response of teleost erythrocytes or red blood cells (RBCs) under vaccine stimulation. Moreover, the unfolded protein response (UPR

Indexed as

Endoplasmic Reticulum StressErythrocytesUnfolded Protein ResponseViral VaccinesAnimalsAutophagyViral Vaccinesantiviral immune responsecryo-SXTendoplasmic reticulum stressred blood cellsSR-µFTIRvaccine

Identifiers

PMID40252498
PMCPMC12162347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.