Evidence map›Paper›PMID 40252148›Full record

ArticleEuropean journal of nutrition2025

Exploring the association between dietary inflammatory index (DII) and different types of skin cancer: a cross-sectional study from NHANES 1999-2018.

Dongfan Wei, Wen Xu, Xiuzu Song

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Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

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5 · Who and what money

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3 authors.

Dongfan WeiDepartment of Dermatology, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, West Lake Road 38, Hangzhou, 310009, People's Republic of China.
Wen XuDepartment of Dermatology, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, West Lake Road 38, Hangzhou, 310009, People's Republic of China.
Xiuzu SongDepartment of Dermatology, Affiliated Hangzhou Dermatology Hospital, Hangzhou Third People's Hospital, Zhejiang University School of Medicine, West Lake Road 38, Hangzhou, 310009, People's Republic of China. songxiuzu@sina.com.ORCID http://orcid.org/0000-0002-0747-2516

Funding

Major Health Science and Technology Project of Hangzhou Z20220040Major Science and Technology Project of Zhejiang Province and the State Administration of Traditional Chinese Medicine GZY-ZJ-KJ-2023035Zhejiang Provincial Natural Science Foundation in China LY23H110001
6 · The paper itself

Abstract

backgroundThe potential role of diet-related inflammatory responses in skin carcinogenesis is gaining increasing recognition. This study investigated the association between the Dietary Inflammatory Index (DII) and different types of skin cancer in the United States general population.

methodsThe study analyzed cross-sectional data on 45,409 participants in the 1999-2018 National Health and Nutrition Examination Survey (NHANES). The association between the DII and different types of skin cancer was estimated using weighted multivariable logistic regression, and its non-linearity was examined using restricted cubic spline (RCS) regression. Subgroup analyses were stratified by age, sex, race, body mass index, hypertension status, diabetes status, and frequency of skin-protecting behaviors.

resultsThe adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for melanoma were 1.54 (1.02-2.35), 1.67 (1.02-2.73), and 1.55 (0.86-2.80) for the second, third, and fourth DII quartiles, respectively, compared with the first quartile. The adjusted ORs with 95% CIs for non-melanoma skin cancer (NMSC) were 0.90 (0.68-1.19), 0.96 (0.69-1.35), and 1.01 (0.70-1.45) for the second, third, and fourth DII quartiles, respectively, compared with the first quartile. The RCS curves showed no overall or non-linear significant association between DII and melanoma prevalence (P = 0.240, Pnon-linearity = 0.144) or NMSC (P = 0.068, Pnon-linearity = 0.410).

conclusionThis study suggests that Compared with participants in DII quartile 1, those in DII quartiles 2 and 3 had a significantly increased risk of melanoma, whereas those in quartile 4 did not. These findings underscore the potential role of dietary inflammation in melanoma etiology and highlight the importance of further research to better understand and mitigate this risk factor.

Indexed as

DietInflammationSkin NeoplasmsAdultAgedCross-Sectional StudiesFemaleHumansMaleMelanomaMiddle AgedNutrition SurveysRisk FactorsUnited StatesCross-sectional studyDietary inflammatory indexMelanomaNational health and nutrition examination surveyNon-melanoma skin cancerSkin cancer

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.