ArticleRheumatology international2025
The natural course of health-related quality of life in patients with clinically suspect arthralgia: a longitudinal study in progressors and non-progressors to rheumatoid arthritis.
Article in Rheumatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Infrared thermography in the detection of arthritis: a systematic review of diagnostic performance compared with joint ultrasound.Rheumatology international · 2026Pooled it
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Authors and funding
7 authors.
Funding
Abstract
Individuals with clinically suspect arthralgia (CSA) are at risk of developing rheumatoid arthritis (RA). It is unknown whether CSA patients have a deprived health-related quality-of-life (HRQoL), how this develops over time, and whether it differs between those who develop RA and those who do not. Using three unique cohorts, we explored the course of HRQoL in CSA patients and after inflammatory arthritis (IA, in this case defined as being either undifferentiated arthritis (UA) or RA) diagnosis. Longitudinal cohort data were used from two CSA cohorts (n = 507) and an IA cohort (n = 282). HRQoL as measured with the EuroQol-5 Dimensions-5 levels (EQ-5D-5 L) questionnaire was compared between CSA patients who develop IA and who do not. We estimated the course of EQ-5D-5 L scores with linear mixed models. In addition, autoantibody-positive and -negative patients were compared. As patients developed IA, their mean EQ-5D-5 L scores deteriorated with 0.12 points (0.03-0.22) over two years, with mobility and usual activities most impacted. Self-care and pain/discomfort were already impacted longer before the diagnosis. Treatment initiation after IA diagnosis showcased an improvement of 0.13 (0.09-0.16) points within 4 months, particularly in the self-care and pain/discomfort dimensions, stabilizing thereafter. In CSA patients who did not develop IA, HRQoL remained stable with a minor improvement of 0.05 (0.02-0.08) points over 2 years. Autoantibody-status had no impact. HRQoL deteriorates before IA diagnosis but improves after treatment initiation. CSA patients who do not develop IA experience stable HRQoL. These findings suggest that early intervention in CSA could prevent deterioration in HRQoL, supporting the potential value of treatment in the CSA phase.
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