Evidence map›Paper›PMID 40252097›Full record

ArticleJournal of cancer research and clinical oncology2025

TROAP promotes esophageal squamous cell carcinoma progression via the PI3K/AKT pathway.

Liqiang Shi, Yajie Zhang, Cong Yang, Yaxin Wang, Yichao Han, Chuanyin Li, Yun Yang, Dong Dong, Mingyuan Du, Hecheng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liqiang Shi *Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Yajie Zhang *Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Cong Yang *Cancer Center, School of Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Yaxin WangDepartment of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Yichao HanDepartment of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Chuanyin LiDepartment of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Yun YangKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Sciences, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China.
Dong DongDepartment of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Mingyuan DuDepartment of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Hecheng LiDepartment of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China. lihecheng2000@hotmail.com.

Funding

National Natural Science Foundation of China 82072557
6 · The paper itself

Abstract

purposeTrophinin-associated protein (TROAP) plays a crucial role in various human cancers. However, its involvement in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to explore the clinical significance and biological function of TROAP in ESCC.

methodsThe expression and clinical relevance of TROAP in ESCC were analyze using GEO and TCGA databases. TROAP expression in ESCC samples was further validated by qRT-PCR, western blotting, and immunohistochemistry. In vitro and in vivo experiments were performed to assess TROAP's role in ESCC progression. RNA-seq analysis followed by western blotting and pathway-specific activator were conducted to explore the underlying mechanism.

resultsTROAP was found to be overexpressed in ESCC and was positively correlated with higher histological grade and advanced clinical stage. Overexpression of TROAP promoted the proliferation, migration, and invasion of ESCC cells in vitro, whereas knockdown of TROAP suppressed ESCC progression both in vitro and in vivo. Mechanistically, TROAP facilitated ESCC progression by activating PI3K/AKT signaling pathway.

conclusionThis study revealed that TROAP promotes ESCC progression via activating PI3K/AKT pathway, suggesting that TROAP might be a promising therapeutic target for ESCC.

Indexed as

Cell Adhesion MoleculesEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CCell Adhesion MoleculesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktEsophageal squamous cell carcinomaMalignant phenotypePI3K/AKTTROAP

Identifiers

PMID40252097
PMCPMC12009240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.