Evidence map›Paper›PMID 40252087›Full record

Trial reportExperimental brain research2025

Anodal transcranial direct current stimulation combined with physical exercise increases postural sway in Parkinson's disease: a double-blind and cross-over study.

Pedro Paulo Gutierrez, Diego Orcioli-Silva, Gabriel Antonio Gazziero Moraca, Beatriz Regina Legutke, Thiago Martins Sirico, Victor Spiandor Beretta, José Angelo Barela

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pedro Paulo GutierrezInstitute of Biosciences, Department of Physical Education, São Paulo State University (UNESP), Rio Claro, SP, Brazil.ORCID http://orcid.org/0000-0001-5377-1464
Diego Orcioli-SilvaInstitute of Biosciences, Department of Physical Education, São Paulo State University (UNESP), Rio Claro, SP, Brazil. diego_orcioli@hotmail.com.ORCID http://orcid.org/0000-0002-2278-8092
Gabriel Antonio Gazziero MoracaInstitute of Biosciences, Department of Physical Education, São Paulo State University (UNESP), Rio Claro, SP, Brazil.ORCID http://orcid.org/0000-0002-9867-1376
Beatriz Regina LegutkeInstitute of Biosciences, Department of Physical Education, São Paulo State University (UNESP), Rio Claro, SP, Brazil.ORCID http://orcid.org/0000-0002-2849-4554
Thiago Martins SiricoInstitute of Biosciences, Department of Physical Education, São Paulo State University (UNESP), Rio Claro, SP, Brazil.ORCID http://orcid.org/0009-0009-7261-6123
Victor Spiandor BerettaSchool of Technology and Sciences, Department of Physical Education, São Paulo State University (UNESP), SP, Presidente Prudente, Brazil.ORCID http://orcid.org/0000-0002-4640-7733
José Angelo BarelaInstitute of Biosciences, Department of Physical Education, São Paulo State University (UNESP), Rio Claro, SP, Brazil.ORCID http://orcid.org/0000-0003-0951-254X

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance code 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/12656-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/02950-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/14143-0
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) has shown promising effects on postural control in people with Parkinson's disease (PwPD). However, the characteristics of the stimulation, such as the specific cortical area targeted and combination with exercise, seem to influence the tDCS effects. Therefore, analyzing these factors is essential for identifying key characteristics and optimizing rehabilitation protocols for postural control in PD.We aimed to analyze the efficacy of tDCS over the primary motor (M1) and pre-frontal cortices (PFC) combined with aerobic exercise on postural control in PwPD. Twenty-one PwPD participated in this crossover, randomized, and double-blind study. The intervention consisted of exercising on a treadmill at moderate intensity for 30 min while receiving the stimulation. tDCS was applied during the central 20 min of exercise over M1, PFC, or sham on 3 different days. Three one-minute trials were conducted with participants standing still on a force platform to assess the center of pressure parameters in anteroposterior (AP) and mediolateral (ML) directions in pre- and post-intervention. Time*stimulation interaction was observed for sway area (p = 0.038) and sway mean amplitude in both the AP (p = 0.009) and ML directions (p = 0.059, marginal effect). Post-hoc analysis indicated a larger sway area and mean amplitude in both directions post-intervention compared to pre-intervention after tDCS application to the M1 and PFC. No significant differences were observed for the sham condition. Our findings suggest that the combination of exercise and tDCS, regardless of the area stimulated, modifies postural control in PwPD, leading to a larger sway.

Indexed as

ExerciseExercise TherapyMotor CortexParkinson DiseasePostural BalancePrefrontal CortexTranscranial Direct Current StimulationAgedCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedBalanceNeurodegenerative diseasePhysical activitytDCS

Identifiers

PMID40252087

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.