Evidence map›Paper›PMID 40252050›Full record

ArticleEpigenetics2025

Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes.

Ji Sun Koo, Qiansheng Zhan, Huiping Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. mEnvironmental epigenetics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ji Sun KooDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Qiansheng ZhanDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Huiping ZhangDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-4902-0104

Funding

Identifying Brain Epitranscriptomic Changes Associated with Alcohol Use DisorderR01AA029758 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Huiping Zhang · 2022 to 2026
$2.8M
Brain microRNA-mRNA regulatory networks and alcohol use disordersR01AA025080 · NIAAA · YALE UNIVERSITY · PI ZHANG, HUIPING · 2016 to 2020
$1.7M
NIAAA NIH HHS R01 AA025080NIAAA NIH HHS R01 AA029758
6 · The paper itself

Abstract

This study examines how the alcohol metabolite acetaldehyde modulates mRNA methylation and expression of ethanol-metabolizing genes, uncovering its epigenetic role in ethanol metabolism. Using neuron-like (SH-SY5Y) and non-neuronal (SW620) cellular models, we examined the effects of chronic intermittent acetaldehyde (CIA) exposure and subsequent withdrawal (CIA+WD) on global RNA m6A modifications and the methylation and expression of three brain ethanol-metabolizing genes:

Indexed as

AcetaldehydeAldehyde Dehydrogenase, MitochondrialCytochrome P-450 CYP2E1EthanolRNA, MessengerAnimalsCell Line, TumorDNA MethylationEpigenesis, GeneticHumansAcetaldehydeAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanCytochrome P-450 CYP2E1EthanolRNA, Messengeradenocarcinoma cell line SW620alcohol-metabolizing enzyme geneschronic intermittent acetaldehyde exposureGlobal m6A RNA methylationMazF-RT-qPCRmRNA stop codon region m6A modificationsneuroblastoma cell line SH-SY5Y

Identifiers

PMID40252050
PMCPMC12013419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.