Evidence map›Paper›PMID 40251970›Full record

SynthesisClinical cardiology2025

Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials.

Kiarash Tavakoli, Negin Sadat Hosseini Mohammadi, Pegah Bahiraie, Sahar Saeidi, Farhad Shaker, Arman Soltani Moghadam, Sara Montazeri Namin, Habib Rahban, Shubhadarshini Pawar, Masih Tajdini and 8 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kiarash TavakoliTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-1233-4166
Negin Sadat Hosseini MohammadiTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0002-9477-6584
Pegah BahiraieSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sahar SaeidiTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Farhad ShakerTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0009-0003-5987-9873
Arman Soltani MoghadamTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Sara Montazeri NaminTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Habib RahbanCardiovascular Research Foundation of Southern California, Beverly Hills, CA, USA.ORCID http://orcid.org/0000-0002-7679-1457
Shubhadarshini PawarCedars Sinai Medical Center, California, Los Angeles, USA.
Masih TajdiniTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Hamidreza SoleimaniTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0003-2802-4613
Yaser JenabTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Yousif AhmadYale School of Medicine, Yale University, New Haven, CT, USA.
Fady Hany IskanderDepartment of Cardiology, Medstar Union Memorial Hospital, Baltimore, MD, USA.
Mohamad AlkhouliDepartment of Cardiology, Mayo Clinic School of Medicine, Rochester, MN, USA.
Raj MakkarCedars Sinai Medical Center, California, Los Angeles, USA.
Aakriti GuptaCedars Sinai Medical Center, California, Los Angeles, USA.
Kaveh HosseiniTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0000-0001-5676-3099

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundComparisons of outcomes after transcatheter aortic valve replacement with balloon-expandable (BEV) versus self-expanding (SEV) valves are limited. HYPOTHESIS: This study aimed to compare clinical and hemodynamic outcomes of BEV and SEV at short-term (30 days), midterm (1 year), and long-term (> 1 year) endpoints.

methodsPubMed, Embase, Scopus, and Cochrane Library databases were searched until July 2024 for randomized controlled trials. Random-effect model (DerSimonian-Laird method) was used to pool the risk ratios (RR), mean differences, and 95% confidence intervals (CI).

resultsA total of 10 studies comprising 4325 patients (2295 BEV, 2030 SEV) were included. In short-term, cardiovascular (RR: 0.56, 95% CI: 0.36-0.87) and all-cause mortality (RR: 0.54, 95% CI: 0.35-0.81) were lower in the BEV group. Risk of moderate to severe paravalvular leak (PVL) was lower among BEV patients in short-term (RR: 0.28, 95% CI: 0.17-0.49) and long-term (RR: 0.28, 95% CI: 0.1-0.79). A limited number of studies showed a greater risk of clinical valve thrombosis on BEV in midterm and long-term. The need for permanent pacemaker implantation was lower in BEV at both short-term (RR: 0.56, 95% CI: 0.37-0.87), and midterm (RR: 0.78, 95% CI: 0.64-0.94). The SEV group had a larger effective orifice area with lower mean transvalvular pressure gradient at all endpoints.

conclusionsBEV is associated with reduced risk of clinical outcomes in short-term; however, most differences diminish in longer evaluations, except for moderate to severe PVL, which remains elevated for SEV. SEVs had better hemodynamic results and lower risk of clinical valve thrombosis.

Indexed as

Aortic ValveAortic Valve StenosisBalloon ValvuloplastyHeart Valve ProsthesisTranscatheter Aortic Valve ReplacementHemodynamicsHumansProsthesis DesignRandomized Controlled Trials as TopicTime FactorsTreatment Outcomeaortic stenosisballoon‐expandable valvesmeta‐analysisself‐expanding valvesTAVRtranscatheter aortic valve replacement

Identifiers

PMID40251970
PMCPMC12008748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.