ArticleSchizophrenia bulletin2026
Abdominal Ultrasound Stimulation Alleviates Negative Symptoms Through Modulation of Serotonin Signaling and Gut Microbiota in the MK-801 Model of Schizophrenia.
Article in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
background and hypothesisAbdominal low-intensity pulsed ultrasound (LIPUS) stimulation has potential as a novel therapeutic strategy against neuroinflammation via inhibition of inflammatory responses in the colon. This study aimed to evaluate whether abdominal LIPUS could alleviate MK-801-induced schizophrenia-like negative symptoms through gut-brain communication. STUDY
designRats administered with MK-801 were treated daily for 5 days with either LIPUS or Lactobacillus plantarum PS128, while another group of MK-801-administered rats received no treatment. Following LIPUS or PS128 treatment, rats underwent behavioral testing, western blot analysis, and histological examination. Changes in the gut bacteria composition were examined through 16S rRNA sequencing analysis. STUDY
resultsMK-801 administration reduced NMDAR1 and VGAT expression in the medial prefrontal cortex (mPFC) of rats, leading to an imbalance in the excitation/inhibition (E/I) ratio. It also decreased 5-HT1AR and 5-HT2AR density, resulting in reduced concentrations of dopamine and serotonin (5-HT). This induced prepulse inhibition, anhedonia, and social withdrawal behaviors, accompanied by a reduction in gut microbiota diversity. Abdominal LIPUS stimulation effectively lessened the MK-801-induced reduction in gut microbiota diversity, restored NMDAR1, 5-HT1AR, and 5-HT2AR density, enhanced dopaminergic neuron activity, and increased dopamine and 5-HT release in the mPFC, thereby reversing behavioral abnormalities.
conclusionsThese results suggest that abdominal LIPUS alleviates MK-801-induced schizophrenia-like negative symptoms by modulating serotonin signaling and the gut microbiota.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.