ArticleGenes, brain, and behavior2025
Expression of GDAP1 Gene Correlates With Alcohol Deprivation Effect.
Article in Genes, brain, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- [Analysis of potential association of alcohol exposure with femoral head osteonecrosis and construction of a diagnostic model using machine learning].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Alcohol addiction is a widespread disease, and the exact causes and consequences are still not fully determined. Neurotransmitters and neuronal circuits are not only the target structure of alcohol and responsible for its direct effects but also play a central role in the development of addiction. A gene that has been linked to alcohol use disorder in recent studies is the ganglioside-induced differentiation-associated protein 1 (GDAP1) gene. The present study focuses on the hippocampus, a brain region particularly vulnerable to alcohol and rich in Gdap1 gene expression. Using an established drinking model, alcohol drinking behavior was induced in adult male Long Evans rats. After 6 weeks of voluntary alcohol intake, followed by 2 weeks of deprivation, the animals were divided into two groups based on the alcohol deprivation effect (ADE). Gdap1 gene expression was measured with real-time PCR in the hippocampus. Results reveal significantly decreased mRNA expression in the high ADE group compared to the low ADE group. This decrease was specifically detected within the cornu ammonis 3 (CA3) region. Gdap1 expression in this region also negatively correlated with ADE in all animals. Taken together, results indicate that Gdap1 might not only be associated with alcohol consumption but might even play a role in alcohol dependence.
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Registered trials
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