Evidence map›Paper›PMID 40251781›Full record

Trial reportActa paediatrica (Oslo, Norway : 1992)2025

Neurodevelopmental Outcomes of Very Low Birth Weight Infants Following Extrauterine Placental Perfusion: A Follow-Up Study.

Benjamin Kuehne, Martin Hellmich, Eva Heine, Angela Kribs, Katrin Mehler, André Oberthuer

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03916159 (Extrauterine Placental Transfusion In Neonatal Resuscitation), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03916159 nacompletednot on this map

Extrauterine Placental Transfusion In Neonatal Resuscitation (EXPLAIN) of Very Low Birth Weight Infants (VLBW): A Randomized Clinical Trial

TypeinterventionalSponsorUniversitätsklinikum KölnRan2019 to 2023Enrolled60ConditionsVery Low Birth Weight Infant, Placental Transfusion, AnemiaArmsExtrauterine placental transfusion (Intervention group), Delayed cord clamping (Control group)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benjamin KuehneDivision of Neonatology, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, University of Cologne, Cologne, Germany.ORCID 0000-0003-3131-8794
Martin HellmichFaculty of Medicine and University Hospital Cologne, Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
Eva HeineDivision of Neonatology, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, University of Cologne, Cologne, Germany.
Angela KribsDivision of Neonatology, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, University of Cologne, Cologne, Germany.
Katrin MehlerDivision of Neonatology, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, University of Cologne, Cologne, Germany.ORCID 0000-0002-3052-2147
André OberthuerDivision of Neonatology, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, University of Cologne, Cologne, Germany.

Funding

Marga und Walter Boll-Stiftung 210-01.01-19the German Interdisciplinary Association for Intensive Care and Emergency Medicine
6 · The paper itself

Abstract

aimExtrauterine placental perfusion (EPP) may be a feasible cord clamping strategy in very low birth weight (VLBW) infants to support neonatal transition. However, the impact of EPP on neurodevelopment remains unclear. The study aimed to compare the effects of EPP with time-based delayed cord clamping (DCC) on neurodevelopmental outcomes.

methodsThis follow-up study of the randomised controlled EXPLAIN (Extrauterine Placental Transfusion in Resuscitation of Very Low Birth Weight Infants) trial (ClinicalTrials.gov Identifier: NCT03916159) was conducted at a tertiary perinatal centre from 2021 to 2023. Antenatally randomised VLBW infants received either EPP or DCC (> 30 s). Neurodevelopment was assessed at 24 months of corrected age using the Bayley Scales of Infant and Toddler Development, Third Edition. Data analysis was intention-to-treat.

resultsOf 59 infants enrolled, 54 (92%) participated in the follow-up (27 EPP, 27 DCC). Median age at assessment was 24.3 months (range 23.5-25.0); 28 (52%) were male. Infant characteristics and short-term outcomes were similar between groups. No relevant differences were observed in median cognitive, motor or language scores or in rates of cerebral palsy, hearing, or visual impairment.

conclusionThe neurodevelopment of the VLBW infants who received EPP and DCC was comparable, suggesting that EPP may be a viable alternative.

Indexed as

Child DevelopmentInfant, Very Low Birth WeightUmbilical Cord ClampingFemaleFollow-Up StudiesHumansInfantInfant, NewbornMalePregnancyextrauterine placental perfusionneurodevelopmental outcomephysiological based cord clampingvery low birth weight infants

Identifiers

PMID40251781
PMCPMC12336934

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.