ArticleDiabetology & metabolic syndrome2025
Association between estimated glucose disposal rate and future cardiovascular disease risk across glucose metabolism status: a prospective cohort study.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Link between C-reactive protein-triglyceride glucose index and cardiovascular disease risk in diverse glycemic statuses: a nationwide prospective cohort study.BMC cardiovascular disorders · 2026Article
- Associations of Insulin Sensitivity with Risk of All-Cause and Cause-Specific Dementia: A Prospective Cohort Study.Molecular neurobiology · 2026Article
- Estimated glucose disposal rate (eGDR) predicts rehospitalization & death in acute decompensated heart failure in the elderly.Heart and vessels · 2026Article
- Changes in estimated glucose disposal rate and future stroke risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3.Scientific reports · 2026Article
- Assessment of seven insulin resistance surrogate indexes for predicting cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.Cardiovascular diabetology · 2026Article
- Metabolic score for visceral fat profiles and incident cardiovascular disease in adults with CKM syndrome stages 0-3: a CHARLS longitudinal study.BMC cardiovascular disorders · 2026Article
- Associations between estimated glucose disposal rate and age-related ocular diseases in cardiovascular-kidney-metabolic syndrome stages 0-3: a large prospective cohort study.BMJ open ophthalmology · 2025Article
- Association between estimated glucose disposal rate and diabetes mellitus incidence in middle-aged and elderly adults and development of predictive model: evidence from two prospective longitudinal studies.BMC endocrine disorders · 2025Article
- Longitudinal changes in estimated glucose disposal rate and risk of cardiovascular disease among adults with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.European journal of medical research · 2025Article
- The association between insulin resistance assessed by estimated glucose disposal rate and stroke prevalence and mortality in non-diabetic people: evidence from two prospective cohorts.Diabetology & metabolic syndrome · 2025Article
- Evaluating the role of insulin resistance in chronic intestinal health issues: NHANES study findings.Frontiers in nutrition · 2025Article
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7 authors.
Funding
Abstract
backgroundCardiovascular disease (CVD) remains a major global health challenge, particularly affected by glucose metabolism status. However, the relationship between estimated glucose disposal rate (eGDR) and future CVD risk across different glucose metabolism status remains unclear.
methodsWe analyzed data from the China Health and Retirement Longitudinal Study (2011-2020) of participants aged ≥ 45 years. The eGDR was calculated using waist circumference, hypertension status, and HbA1c levels. CVD events (stroke or cardiac events) were the outcome. Participants were categorized by glucose metabolism status (normoglycemia, prediabetes, diabetes). Cox proportional hazards models and restricted cubic splines were used to assess associations and potential non-linear relationships.
resultsAmong 7,828 participants (52.84% male, mean age 59.01 ± 9.21 years) followed for an average of 8.29 years, 1,944 participants (24.83%) developed CVD. Higher eGDR was inversely associated with CVD risk across all glucose metabolism states. Below the inflection points (11.77, 11.15, and 11.56 mg/kg/min for normoglycemia, prediabetes, and diabetes, respectively), each 1-unit increase in eGDR reduced CVD risk by 14% (HR = 0.86, 95%CI: 0.83-0.89), 10% (HR = 0.90, 95%CI: 0.86-0.93), and 14% (HR = 0.86, 95%CI: 0.81-0.91), respectively.
conclusionThe eGDR demonstrates a potentially non-linear inverse association with future CVD risk across different glucose metabolism states.
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