HPV infection incidence and genotype distribution among male patients visiting outpatient departments in Huizhou from 2014 to 2023.

backgroundThere have been no previous studies on male HPV infection in the Huizhou region. This research aims to investigate the HPV infection rate and genotype distribution among male patients in this area, offering valuable insights for developing targeted preventive strategies against HPV infection in male population.

methodsThis study included 1009 male patients from Huizhou Central People’s Hospital who underwent HPV genotype testing between 2014 and 2023. We analyzed the distribution of HPV genotypes by year, age group, and diagnosis. Additionally, clinical data from 308 HPV-positive patients were retrospectively collected, and differences in high-risk vs. low-risk types, single vs. multiple infections, and genotype correlations were analyzed.

resultsThe overall HPV positivity rate was 30.53%, with the positive rate(40.56%) in the 2014–2019 group being significantly higher than that in 2021 (25.56%) and 2022 (24.29%)(p<0.05). The most common genotypes were HPV6, HPV52, HPV11, and HPV16. HPV infection was most prevalent in the 41–50 age group, while males aged ≤ 30 were predominantly infected with low-risk types (41.73%). The 31–40 age group had a higher prevalence of high-risk types (52.07%), with males under 50 primarily infected with low-risk HPV6, while those aged 51 and above mostly had high-risk HPV52 infections. The highest HPV positivity rate was found in the viral wart group (79.01%). Single infections were more common (64.29%), with co-infection of HPV6 and HPV16 being the most prevalent type.

conclusionThe overall HPV infection rate was relatively high among outpatient male patients in Huizhou, with single infections being predominant. Additionally, HPV infection rates exhibited significant differences across various years, age groups, and diagnostic types, suggesting that these factors should be considered when formulating HPV prevention and control strategies.