Evidence map›Paper›PMID 40251571›Full record

ArticleBMC ophthalmology2025

Multiple choroidal granulomas in lymphomatoid granulomatosis: a case report.

Ryo Taguchi, Yoshiaki Tanaka, Machiko Shimmura, Hiroko Takano, Akihiro Kakehashi, Toshikatsu Kaburaki

Abstract readCase Reports
In one paragraph

Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryo TaguchiDepartment of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan. ryo0616tag.jichi@gmail.com.
Yoshiaki TanakaDepartment of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan.
Machiko ShimmuraDepartment of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan.
Hiroko TakanoDepartment of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan.
Akihiro KakehashiDepartment of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan.
Toshikatsu KaburakiDepartment of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder predominantly affecting middle-aged men. The disease occurs primarily in the lungs; however, reports of lesions in intraocular regions are scarce. Herein, we report a case of choroidal granulomas in a patient with LYG. CASE PRESENTATION: A 55-year-old male patient presented to a respiratory specialist with pneumonia of unknown cause. His serum-soluble IL-2 receptor level was highly elevated, and transbronchial lung biopsies revealed granulomatous lesions. Sarcoidosis was suspected, and an ophthalmological examination was performed. The best-corrected visual acuity was 1.2 in both eyes. Although no cells were present in the anterior chambers or anterior vitreous in either eye, multiple large yellowish-white exudates on the fundus of the right eye and soft exudates around the optic disc in the left eye were observed. Optical coherence tomography revealed choroidal granulomas consistent with the yellowish-white lesions in the right eye. Fluorescein angiography revealed tissue staining in the right eye consistent with granulomatous choroidal lesions. Both eyes showed capillaritis, mainly in the nasal retina. Subsequently, a thoracoscopic left lung biopsy led to a pathological diagnosis of LYG, and chemotherapy was initiated. Thereafter, the yellowish-white exudates gradually scarred, and the choroidal granulomas and soft exudates disappeared; thus, a vitreous biopsy was not performed. After autologous hematopoietic stem cell transplantation, the LYG was in remission. No ocular lesion recurrence was observed in the subsequent 18 months.

conclusionsLYG may cause multiple large choroidal granulomas.

Indexed as

Choroid DiseasesGranulomaLymphomatoid GranulomatosisFluorescein AngiographyHumansMaleMiddle AgedTomography, Optical CoherenceVisual AcuityB-cell lymphoproliferative disorderCase reportChoroidal granulomasLungLymphomatoid granulomatosis

Identifiers

PMID40251571
PMCPMC12007125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.