Trial reportBMC oral health2025
In vivo and in situ evaluation of innovative approaches in dentin hypersensitivity treatment.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04568473 (Effectiveness of Bioactive Resin Based Varnish and Fluoride Varnish Containing Xylitol-coated Particles Versus Sodium Fluoride Varnish in Management of Teeth Hypersensitivity in Adult Patients Over Eight Weeks), which is not on this map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Bioactive Resin Based Varnish and Fluoride Varnish Containing Xylitol-coated Particles Versus Sodium Fluoride Varnish in Management of Teeth Hypersensitivity in Adult Patients Over Eight Weeks: a Randomized Clinical Trial.
Who cites it
4 citing papers in PubMed.
- Comparative evaluation of Giomer varnish versus fluoride varnish as desensitizing agents among a group of children with molar incisor hypomineralization: a randomized clinical trial.BMC oral health · 2026Trial
- Effectiveness of S-PRG-based varnish and bioactive glass-based air polishing in the management of dentin hypersensitivity and their effects on tooth color: a 12-month randomized clinical trial.BMC oral health · 2026Trial
- Longevity of different in-office treatments for dentin hypersensitivity: A 6-month randomized and parallel clinical trial.PloS one · 2026Trial
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDentin hypersensitivity (DH) causes transient sharp pain from exposed dentinal tubules, adversely affecting oral health and quality of life. This study compared the efficacy of two innovative treatments against Sodium Fluoride Varnish in reducing DH and occluding dentinal tubules over eight weeks.
methodsThis randomized, triple-blind, three-parallel-arm clinical and in situ study included a total of 63 participants (age range: 26-46 years), each randomly assigned to one of three treatment groups: PRG Barrier Coat, Embrace varnish, or Duraphat varnish. The clinical trial assessed pain intensity was assessed using Visual Analog Scale (VAS) after tactile, evaporative, and thermal stimuli at baseline, 3 min, 2 weeks, 4 weeks, and 8 weeks. The in-situ phase evaluated dentinal tubules occlusion pre- and post-treatment using scanning electron microscopy (SEM) at 2000× magnification. Statistical Analysis was conducted using Kruskal-Wallis and Friedman tests for intergroup and intragroup comparisons, respectively, and Spearman's correlation for pain reduction-tubule occlusion relationship (p < 0.05).
resultsPRG Barrier Coat achieved the highest efficacy with 94.9% pain reduction and 96.9% tubule occlusion. Embrace varnish showed moderate results with 64.3% pain reduction and 69.7% tubule occlusion, while Duraphat varnish provided limited performance with 45.4% pain reduction and 48.3% tubule occlusion. PRG Barrier Coat exhibited the most prolonged effects in reducing dentin hypersensitivity, aligning with its higher tubule occlusion. Embrace varnish demonstrated moderate performance, showing initial pain relief that was less sustained over time. Duraphat varnish provided the least reduction in pain and tubule occlusion, with effects that appeared transient.
conclusionsThis study demonstrated that PRG Barrier Coat and Embrace varnish effectively reduced pain intensity and promoted dentinal tubule occlusion, with PRG Barrier Coat showing the most sustained effects. These findings highlight the importance of dentinal tubule occlusion in DH management and suggest that treatment selection should consider both immediate pain relief and durability of therapeutic effects.
trial registrationClinicalTrials.gov (NCT04568473) on September 23, 2020.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.