Evidence map›Paper›PMID 40251516›Full record

ArticleBMC cardiovascular disorders2025

Predictive Value of Peri-Coronary Fat Attenuation Index in Elderly Non-ST-Elevation Myocardial Infarction and Its Correlation with Platelet to Lymphocyte Ratio.

Yanglei Li, Chen Wang, Qinyue Wang, Siqi Li, Junchao Yang, Hanqin Pan, Ming Li, Xinkai Qu, Yiran Qin, Chunwei Ma and 3 more

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Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Yanglei Li *Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China.
Chen Wang *Department of Radiology, Huadong Hospital, Fudan University, Shanghai, China.
Qinyue Wang *Department of Cardiology, Huadong Hospital, Fudan University, Shanghai, China.
Siqi LiDepartment of Cardiology, Huadong Hospital, Fudan University, Shanghai, China.
Junchao YangDepartment of Information Technology, Huadong Hospital, Fudan University, Shanghai, China.
Hanqin PanDepartment of Cardiology, Huadong Hospital, Fudan University, Shanghai, China.
Ming LiDepartment of Radiology, Huadong Hospital, Fudan University, Shanghai, China.
Xinkai QuDepartment of Cardiology, Huadong Hospital, Fudan University, Shanghai, China.
Yiran QinDepartment of Cardiology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
Chunwei MaDepartment of Genaral Practice, Zhongnan Hospital of Wuhan University, Hubei, China. zn000183@whu.edu.cn.
Lin QiDepartment of Radiology, Huadong Hospital, Fudan University, Shanghai, China. qilin86521@163.com.
Mingxuan LiDepartment of Cardiology, Huadong Hospital, Fudan University, Shanghai, China. 19211280015@fudan.edu.cn.
Kailei ShiDepartment of Cardiology, Huadong Hospital, Fudan University, Shanghai, China. shikailei@fudan.edu.cn.

Funding

Center of geriatric coronary artery disease of Huadong hospital LCXZ2205Science and Technology Planning Project of Shanghai Science and Technology Commission 21Y11910500Shanghai Shenkang hospital development center SHDC22023302the Science and Technology Commission of Shanghai Municipality 22ZR1422000
6 · The paper itself

Abstract

backgroundInflammatory mediators and immune activation can intensify the inflammatory response within atherosclerotic plaques, increasing the risk of plaque rupture and thrombosis. This study aims to compare peri-coronary adipose tissue fat attenuation index (PCAT-FAI) and platelet-to-lymphocyte ratio (PLR) between NSTEMI and SA patients, and explore their combined predictive ability for NSTEMI. PATIENTS AND

methodsThe study included 52 NSTEMI patients aged 65 and older who underwent both CCTA and CAG from January 2020 to December 2022, alongside 52 gender- and age-matched SA patients, and 52 control patients. PCAT-volume and PCAT-FAI were measured using Siemens VB20.0, and PLR was calculated from peripheral blood tests.

resultsAmong 156 patients, NSTEMI patients had significantly higher PCAT volume (12.13 ± 5.32 mm³) compared to SA (8.39 ± 4.10 mm³, p < 0.001) and controls (6.28 ± 3.40 mm³, p < 0.001). They also had higher PCAT-FAI (-76.28 ± 5.33 HU) than SA (-82.87 ± 6.19 HU, p < 0.001) and controls (-84.19 ± 5.74 HU, p < 0.001). PLR was higher in NSTEMI patients (178.27 ± 107.18) compared to SA (115.54 ± 45.28, p = 0.002) and controls (116.09 ± 38.09, p = 0.006), with no significant difference between SA and controls (p = 1.000). PCAT-FAI correlated with PLR (CC: 0.298; P < 0.01). Combining PLR and PCAT-FAI predicted NSTEMI with an AUC of 0.799 (95% CI, 0.715-0.883).

conclusionHigher PCAT-FAI and PLR in NSTEMI patients highlight the role of adipose tissue inflammation and thrombosis in coronary artery disease progression. Combined assessment of PCAT-FAI and PLR has potential value in predicting the adverse progression of atherosclerotic plaques.

Indexed as

Adipose TissueAdiposityBlood PlateletsCoronary AngiographyCoronary Artery DiseaseLymphocytesNon-ST Elevated Myocardial InfarctionAgedAged, 80 and overAge FactorsCase-Control StudiesFemaleHumansLymphocyte CountMalePlatelet CountElderlyFat attenuation indexNon-ST-elevation myocardial infarctionPeri-coronary adipose tissuePlatelet to lymphocyte ratio

Identifiers

PMID40251516
PMCPMC12007298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.