Evidence map›Paper›PMID 40251456›Full record

ReviewCardiovascular toxicology2025

Essential and Non-Essential Metals and Metalloids and Their Role in Atherosclerosis.

Pierce L Massie, Marcus Garcia, Aerlin Decker, Rui Liu, Milad MazloumiBakhshayesh, Deepali Kulkarni, Matthew P Justus, Jorge Gallardo, Avalon Abrums, Kristin Markle and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cardiovascular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pierce L MassieDepartment of Surgery, University of New Mexico School of Medicine, MSC10-5610, Albuquerque, NM, 87131, USA.
Marcus GarciaDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, USA.
Aerlin DeckerDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, USA.
Rui LiuDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, USA.
Milad MazloumiBakhshayeshDepartment of Biomedical Engineering, School of Engineering, University of New Mexico, Albuquerque, USA.
Deepali KulkarniDepartment of Surgery, University of New Mexico School of Medicine, MSC10-5610, Albuquerque, NM, 87131, USA.
Matthew P JustusDepartment of Biomedical Engineering, School of Engineering, University of New Mexico, Albuquerque, USA.
Jorge GallardoDepartment of Surgery, University of New Mexico School of Medicine, MSC10-5610, Albuquerque, NM, 87131, USA.
Avalon AbrumsDepartment of Surgery, University of New Mexico School of Medicine, MSC10-5610, Albuquerque, NM, 87131, USA.
Kristin MarkleDepartment of Surgery, University of New Mexico School of Medicine, MSC10-5610, Albuquerque, NM, 87131, USA.
Carolyn PaceDepartment of Surgery, University of New Mexico School of Medicine, MSC10-5610, Albuquerque, NM, 87131, USA.
Matthew CampenDepartment of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, USA.
Ross M ClarkDepartment of Surgery, University of New Mexico School of Medicine, MSC10-5610, Albuquerque, NM, 87131, USA. rmclark@salud.unm.edu.ORCID 0000-0003-3712-8414

Funding

University of New Mexico Clinical and Translational Science CenterKL2TR001448 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANNON, JUDY LIN · 2015 to 2024
$3.5M
NCATS NIH HHS KL2TR001448
6 · The paper itself

Abstract

Peripheral arterial disease (PAD) is becoming more prevalent in the aging developed world and can have significant functional impacts on patients. There is a recent recognition that environmental toxicants such as circulating metals and metalloids may contribute to the pathogenesis of atherosclerotic disease, but the mechanisms are complex. While the broad toxic biologic effects of metals in human systems have been extensively reviewed, the role of non-essential exposure and essential metal aberrancy in PAD specifically is less frequently discussed. This review of the literature describes current scientific knowledge regarding the individual roles several major metals and metalloids play in atherogenesis and highlights areas where a dearth of data exist. The roles of lead (Pb), arsenic (As), cadmium (Cd), iron (Fe), copper (Cu), selenium (Se) are included. Contemporary outcomes of therapeutic trials aimed at chelation therapy of circulating metals to impact cardiovascular outcomes are also discussed. This review highlights the supported notion of differential metal presence within peripheral plaques themselves, although distinguishing their roles within these plaques requires further illumination.

Indexed as

ArteriesAtherosclerosisEnvironmental PollutantsMetalloidsMetalsMetals, HeavyPeripheral Arterial DiseaseAnimalsHumansPlaque, AtheroscleroticRisk AssessmentRisk FactorsEnvironmental PollutantsMetalloidsMetalsMetals, HeavyAtherosclerosisCardiovascular diseaseCarotid artery stenosisMetalMetalloid

Identifiers

PMID40251456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.