ArticleScientific reports2025
The composition of single-donor apheresis platelet concentrates is influenced by the age of the donor.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The aging population often faces health issues that sometimes necessitate transfusions. Transfusion services are increasingly concerned about the rising number of transfusions and the aging donor population, as both factors are crucial in maintaining the quality of blood donations. In this context, our study aims to measure the bioactive molecule cytokine levels in single donor apheresis platelet concentrates (SDA-PC) based on the donor's age and to determine whether these cytokines, in conjunction with the donor age, could contribute to transfusion adverse reactions (AR). Our findings indicate that well-known platelet molecules such as sCD62P, as well as IL-13, ADAMTS13, MIP-1α, NGAL, MCP-3, HSAA, GDF-15, CX3CL1, and MDC, were present in SDA-PC. Levels of MIP-1α, GDF-15, and sCD62P increased with donor aging, whereas levels of MDC decreased. In conclusion, most of the cytokine levels detected were elevated in cases of AR and with increasing donor age. Notably, GDF-15 was the only cytokine that showed a positive correlation with age in the context of AR.
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