Evidence map›Paper›PMID 40251337›Full record

ArticleScientific reports2025

Identification of unique biomarkers for proliferative diabetic retinopathy with tractional retinal detachment by proteomics profiling of vitreous humor.

Yuyan Liu, Rongjie Wei, Yong Tang, Shuo Sun, Wei Zhang, Yu Zhou, Zhenhua Pan, Quanhong Han, Xiujuan Zhao, Yanhua Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuyan Liu *Tianjin Key Lab of Ophthalmology and Visual Science, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Medical University, Gansu Road 4, Heping District, Tianjin, 300020, China.
Rongjie Wei *School of Medicine, NanKai University, Tianjin, 300071, China.
Yong TangTianjin Key Lab of Ophthalmology and Visual Science, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Medical University, Gansu Road 4, Heping District, Tianjin, 300020, China.
Shuo SunTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China.
Wei ZhangTianjin Key Lab of Ophthalmology and Visual Science, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Medical University, Gansu Road 4, Heping District, Tianjin, 300020, China.
Yu ZhouThe people's Hospital of Jizhou District, Tianjin, 301900, China.
Zhenhua PanDepartment of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Quanhong HanTianjin Key Lab of Ophthalmology and Visual Science, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Medical University, Gansu Road 4, Heping District, Tianjin, 300020, China.
Xiujuan ZhaoDepartment of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China. zhaoxiujuan@tmu.edu.cn.
Yanhua ChuTianjin Key Lab of Ophthalmology and Visual Science, Clinical College of Ophthalmology, Tianjin Eye Hospital, Tianjin Medical University, Gansu Road 4, Heping District, Tianjin, 300020, China. chuchutj@126.com.

Funding

Science and Technology Foundation of Tianjin Eye Hospital YKPY2208Science Foundation of Tianjin Educational Commission Fund 2020KJ157Tianjin Health Research Project T J W J 2 0 2 4 M S 0 3 3Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-016A
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is one of the major complications of diabetes, resulting in severe vision loss. Traction retinal detachment (TRD) is the main factor affecting the effect of proliferative diabetic retinopathy (PDR) surgery. Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) was adopted to analyze the proteomes of the vitreous in the TRD, vitreous hemorrhage (VH) and macular hole (MH) groups. By employing bioinformatics tools for GO and KEGG pathway annotation, as well as conducting protein-protein interaction(PPI) network analysis, we investigated the functional enrichment of proteins in the TRD vitreous and their associated pathways. Additionally, peptide center analysis was performed on the proteomic data to identify key differentially expressed proteins based on screening results. Bioinformatics analysis showed that DEPs is mainly enriched in the complement, the coagulation cascade systems and regulation of actin cytoskeleton. The protein interaction network analysis showed that the central proteins were mainly related to sphingolipid metabolism. APOA4, CHI3L1, LTBP2 were significantly up-regulated in TRD, which were related to the complement system, coagulation cascade and platelet activation, sphingolipid metabolism and other pathways. APOA4 and CHI3L1 protein in patients with TRD group raised significantly in the vitreous humor, shows the potential biomarkers for TRD.

Indexed as

BiomarkersDiabetic RetinopathyProteomeProteomicsRetinal DetachmentVitreous BodyAgedApolipoproteins AChromatography, LiquidComputational BiologyFemaleHumansMaleMiddle AgedProtein Interaction MapsTandem Mass Spectrometryapolipoprotein A-IVApolipoproteins ABiomarkersProteomeAPOA4CHI3L1Diabetic retinopathyLiquid chromatography with tandem mass spectrometry (LC-MS/MS)Sphingolipid metabolismTraction retinal detachment

Identifiers

PMID40251337
PMCPMC12008405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.