Evidence map›Paper›PMID 40251331›Full record

ArticleScientific reports2025

Longitudinal relationship between atherosclerosis and progression of periodontitis in community-dwelling people in Nagasaki Islands Study.

Naofumi Tamaki, Makoto Fukui, Masayasu Kitamura, Hideki Fukuda, Reiko Furugen, Hirotomo Yamanashi, Jun Miyata, Toshiyuki Saito, Takahiro Maeda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naofumi TamakiDepartment of Preventive Dentistry, Kagoshima University Graduate School of Medicine and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City, Kagoshima, 890-8544, Japan. tamanaof@dent.kagoshima-u.ac.jp.
Makoto FukuiDepartment of Hygiene and Oral Health Science, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramotocho, Tokushima City, Tokushima, 770-8504, Japan.
Masayasu KitamuraDepartment of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, 1-7- 1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.
Hideki FukudaNational Institute of Public Health, 2-3-6 Minami, Wako City, Saitama, 354-0026, Japan.
Reiko FurugenDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.
Hirotomo YamanashiDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.
Jun MiyataDepartment of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, 205 Yoshikugicho, Goto City, Nagasaki, 853-8691, Japan.
Toshiyuki SaitoDepartment of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, 1-7- 1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.
Takahiro MaedaDepartment of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few epidemiological studies have explored the longitudinal relationship between atherosclerosis and periodontitis. The aim of this study was to investigate the longitudinal relationship between atherosclerosis and the progression of periodontitis in community-dwelling individuals in Japan. Progression of periodontitis was defined as the presence of the teeth demonstrating a longitudinal loss of proximal attachment ≥ 3 mm during the study period. Oral examinations and subclinical atherosclerosis assessments were performed. The surrogate markers of early-stage atherosclerosis were increased carotid intima-media thickness (cIMT), low ankle-brachial index (ABI), and cardio-ankle vascular index (CAVI). The study included 222 Japanese adults. While CAVI increased significantly in both groups, the prevalence of CAVI ≥ 8 was significantly increased in only the progression group during the study period. Logistic regression analysis indicated that the progression of periodontitis was significantly associated with cIMT. Additionally, CAVI positively correlated with changes in probing pocket depth, while ABI negatively correlated with changes in clinical attachment loss. These results suggest that participants with high cIMT, high CAVI and low ABI had a high risk of periodontitis progression after adjusting for risk factors. In conclusion, subclinical markers of early-stage atherosclerosis are significantly associated with a greater risk of periodontitis progression in community-dwelling Japanese participants.

Indexed as

AtherosclerosisPeriodontitisAdultAgedAnkle Brachial IndexCarotid Intima-Media ThicknessDisease ProgressionFemaleHumansIndependent LivingJapanLongitudinal StudiesMaleMiddle AgedRisk FactorsAnkle-brachial indexAtherosclerosisCardio-ankle vascular indexCarotid intima-media thicknessLongitudinal cohort studyPeriodontitis

Identifiers

PMID40251331
PMCPMC12008378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.