ArticleJournal of perinatology : official journal of the California Perinatal Association2025
The utility of neonatal sequential organ failure assessment in mortality risk in all neonates with suspected late-onset infection.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Heterogeneity of Critical Organ Dysfunction During Late-Onset Bacteremia in Preterm Infants.JAMA network open · 2026Observational
- Neonatal Sepsis as Organ Dysfunction: Prognostic Accuracy and Clinical Utility of the nSOFA in the NICU-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveAssess the utility of the neonatal sequential organ failure assessment score (nSOFA) for evaluation-specific mortality discrimination in all late-onset infection (LOI) evaluations.
methodsRetrospective Cohort of all neonates who had an LOI evaluation from 2012 to 2023 in a single level IV Academic NICU in Florida, USA. The primary outcome was LOI-evaluation-specific mortality.
results1481 neonates had 2916 LOI evaluations with a 3.8% mortality rate. The AUROC for the nSOFA score at evaluation was 0.76 (95% CI 0.71-0.81) and improved to 0.82 (95% CI 0.78-0.87) six hours after. nSOFA ≥2 within 6 h of the start of the LOI was 87% sensitive and 66% specific, with a 99% NPV for mortality, p < 0.0001.
conclusionsThe nSOFA score had good to excellent mortality discrimination at the LOI evaluation level. These results solidify the utility of the nSOFA score as the foundation for a consensus definition of neonatal sepsis.
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Registered trials
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