Evidence map›Paper›PMID 40251266›Full record

ArticleScientific reports2025

Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway.

Yufan Wang, Lei Wang, Hanwen Zhang, Peirou Ren, Xiaowen Cheng, Fandi Hong, Jiaxin Liu, Ruining Zhang, Jun Zhao, Dongxia Gou

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Structural Characterization of a Novel Galactoarabinan fromAntioxidants (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. International journal of molecular sciences · 2026
    Article
  6. Lactose-Free Fermented Milk Production UsingJournal of microbiology and biotechnology · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Exploring the Anticancer Potential ofCurrent issues in molecular biology · 2025
    Review
  11. Molecules (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yufan WangCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China.
Lei WangCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China.
Hanwen ZhangCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China.
Peirou RenCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China.
Xiaowen ChengCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China.
Fandi HongCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China.
Jiaxin LiuJilin Province Product Quality Supervision and Inspection Institute, Changchun, 130103, China.
Ruining ZhangAgriculture College, Yanbian University, Yanbian, 133002, China.
Jun ZhaoCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China.
Dongxia GouCollege of Food Science and Engineering, Changchun University, No.8326 Weixing Street, Changchun, 130022, China. goudx@ccu.edu.cn.

Funding

Changchun University Climbing Program ZPK202123Jilin Provincial Department of Science and Technology YDZJ202101ZYTS077
6 · The paper itself

Abstract

Acanthopanax senticosus is a unique wild resource in Northeast China. Its main active ingredient is a polysaccharide, which has a prominent immunomodulatory effect. In this study, the purified polysaccharide component of Acanthopanax senticosus leaves(ASPS-A1) with strong immunomodulatory activity was isolated by column chromatography, and its structure and properties were characterized by HPGPC, and FT-IR. Results showed that ASPS-A1 is mainly composed of α- 1,4-

Indexed as

Adjuvants, ImmunologicEleutherococcusMAP Kinase Signaling SystemNF-kappa BPolysaccharidesSignal TransductionToll-Like ReceptorsAnimalsCytokinesMacrophagesMiceMolecular Docking SimulationPlant ExtractsRAW 264.7 CellsAdjuvants, ImmunologicCytokinesNF-kappa BPlant ExtractsPolysaccharidesToll-Like ReceptorsAcanthopanax senticosus polysaccharideRAW 264.7 cellsRNA-seqSignaling pathwayStructure characterization

Identifiers

PMID40251266
PMCPMC12008293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.