Evidence map›Paper›PMID 40251249›Full record

ArticleNature biomedical engineering2025

High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques.

Alix Trouillet, Emilie Revol, Florent-Valéry Coen, Florian Fallegger, Aurélie Chanthany, Maude Delacombaz, Laurine Kolly, Ivan Furfaro, Florian Lanz, Vivek Kanumuri and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alix Trouillet *Laboratory for Soft Bioelectronic Interfaces, Neuro X Institute, School of Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, Geneva, Switzerland. alix.trouillet@chuv.ch.ORCID http://orcid.org/0000-0002-4242-0324
Emilie Revol *Laboratory for Soft Bioelectronic Interfaces, Neuro X Institute, School of Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-8483-2239
Florent-Valéry CoenLaboratory for Soft Bioelectronic Interfaces, Neuro X Institute, School of Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, Geneva, Switzerland.ORCID http://orcid.org/0000-0003-1477-8836
Florian FalleggerLaboratory for Soft Bioelectronic Interfaces, Neuro X Institute, School of Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, Geneva, Switzerland.
Aurélie ChanthanyDepartment of Neuroscience, Platform of Translational Neuroscience, University of Fribourg, Fribourg, Switzerland.
Maude DelacombazDepartment of Neuroscience, Platform of Translational Neuroscience, University of Fribourg, Fribourg, Switzerland.
Laurine KollyLaboratory for Soft Bioelectronic Interfaces, Neuro X Institute, School of Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, Geneva, Switzerland.ORCID http://orcid.org/0009-0009-5800-0744
Ivan FurfaroLaboratory for Soft Bioelectronic Interfaces, Neuro X Institute, School of Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-6077-3257
Florian LanzDepartment of Neuroscience, Platform of Translational Neuroscience, University of Fribourg, Fribourg, Switzerland.
Vivek KanumuriEaton-Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Victor AdenisEaton-Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2633-0812
Alejandro Garcia-ChavezEaton-Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
M Christian BrownEaton-Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA.
Lukas AnschuetzDepartment of Otorhinolaryngology, Lausanne University Hospital, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-6927-0664
Jocelyne BlochDepartment of Clinical Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6405-1590
Daniel J LeeEaton-Peabody Laboratories, Department of Otolaryngology, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, USA. DJLEE1@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-5104-4626
Stéphanie P LacourLaboratory for Soft Bioelectronic Interfaces, Neuro X Institute, School of Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, Geneva, Switzerland. stephanie.lacour@epfl.ch.ORCID http://orcid.org/0000-0001-9075-4022

Funding

Fondation Bertarelli (Bertarelli Foundation) n/aSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) BSCGI0_157800Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) CRSII5-183519
6 · The paper itself

Abstract

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engineered a dual-site (brainstem and cortex) implantable system, scaled to macaque anatomy, for the analysis of auditory perception evoked by electrical stimulation of the cochlear nucleus. A soft multichannel ABI, fabricated using thin-film processing, provided high-resolution auditory percepts, with spatially distinct stimulation sites eliciting cortical responses akin to frequency-specific tuning. Behavioural responses collected over several months were sufficiently precise to distinguish stimulations from adjacent channels. Soft multichannel ABIs may aid the rehabilitation of individuals with profound hearing loss who are ineligible for cochlear implants.

Indexed as

Auditory Brain Stem ImplantsAuditory PerceptionCerebral CortexCochlear NucleusAnimalsElectric StimulationHearing LossImplants, ExperimentalMacaca

Identifiers

PMID40251249
PMCPMC12443620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.