Evidence map›Paper›PMID 40251235›Full record

ArticleScientific reports2025

Mendelian randomization study of sleep traits and risk of colorectal cancer.

Olympia Dimopoulou, Harriett Fuller, Rebecca C Richmond, Emmanouil Bouras, Bryony Hayes, Niki Dimou, Neil Murphy, Hermann Brenner, Andrea Gsur, Loic Le Marchand and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Sleep duration, selected circulating biomarkers, and colorectal cancer risk.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Olympia DimopoulouDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. olympia.dimopoulou@bristol.ac.uk.
Harriett FullerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Rebecca C RichmondDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Emmanouil BourasDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
Bryony HayesDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Niki DimouNutrition and Metabolism Branch, International Agency for Research On Cancer-WHO, Lyon, France.
Neil MurphyNutrition and Metabolism Branch, International Agency for Research On Cancer-WHO, Lyon, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Andrea GsurCenter for Cancer Research, Medical University of Vienna, Vienna, Austria.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Victor MorenoOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Rish K PaiDepartment of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Amanda I PhippsPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Caroline Y UmPopulation Science Department, American Cancer Society, Atlanta, GA, USA.
Franzel J B van DuijnhovenDivision of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands.
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Richard M MartinDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Marc J GunterNutrition and Metabolism Branch, International Agency for Research On Cancer-WHO, Lyon, France.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Sarah J LewisDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Yin CaoDivision of Public Health Sciences, Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA.
Konstantinos K TsilidisDepartment of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

Funding

Data sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8M
An integrative omics approach to investigate gene-environment interaction in colorectal cancer riskR01CA273198 · NCI · FRED HUTCHINSON CANCER CENTER · PI William JAMES GAUDERMAN, ULRIKE PETERS · 2023 to 2026
$3.5M
Cancer Research UK C18281/A29019NCI NIH HHS R01 CA273198NCI NIH HHS U01 CA167551World Health Organization 001
6 · The paper itself

Abstract

A potential association of endogenous circadian rhythm disruption with risk of cancer development has been suggested, however, epidemiological evidence for the association of sleep traits with colorectal cancer (CRC) is limited and often contradictory. Here we investigated whether genetically predicted chronotype, insomnia and sleep duration are associated with CRC risk in males, females and overall and according to CRC anatomical subsites using Mendelian randomization (MR). The two-sample inverse variance weighted (IVW) method was applied using summary-level data in up to 58,221 CRC cases and 67,694 controls and genome-wide association data of genetic variants for self-reported sleep traits. Secondary analyses using alternative instruments and sensitivity analyses assessing potential violations of MR assumptions were conducted. Genetically predicted morning preference was associated with 13% lower risk of CRC in men (OR

Indexed as

Colorectal NeoplasmsMendelian Randomization AnalysisSleepCircadian RhythmFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideRisk FactorsSleep Initiation and Maintenance Disorders

Identifiers

PMID40251235
PMCPMC12008275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.