ArticleScientific reports2025
Real-World pharmacovigilance analysis of drug-related conjunctivitis using the FDA adverse event reporting system database.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A Pharmacovigilance Analysis of Ocular Adverse Events Associated with GLP-1 Receptor Agonists.Journal of clinical medicine · 2026Review
- Safety signals of perfluorohexyloctane ophthalmic solution in patients with dry eye disease.Frontiers in medicine · 2026Article
- Real-world landscape of drug-related ocular injuries: a retrospective pharmacovigilance study.Frontiers in pharmacology · 2026Article
- From Pathways to Patients in Atopic Dermatitis: Advanced Systemic Therapies.International journal of molecular sciences · 2025Review
- Chloroquine and hydroxychloroquine-related ocular adverse events in SLE treatment: a real-world disproportionality analysis based on FDA adverse event reporting system (FAERS).Frontiers in pharmacology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Drug-related conjunctivitis can compromise ocular health and quality of life. To evaluate its epidemiology, we analyzed reports from the FDA Adverse Event Reporting System (FAERS) spanning January 2004 to June 2024. The control group in this study comprised individuals using non-target drugs, while the experimental group consisted of individuals using target drugs. Using disproportionality analysis, we identified drugs with a positive signal for conjunctivitis and stratified their risk levels; we also examined induction periods to assess the speed of onset. Among 38 drugs most frequently reported for conjunctivitis, two ophthalmic agents-brimonidine (ROR = 23.04) and latanoprost (ROR = 10.55)-and eight non-ophthalmic drugs, including tralokinumab (ROR = 83.3), dupilumab (ROR = 18.92), and allopurinol (ROR = 5.04), were associated with positive signals. Tralokinumab, brimonidine, dupilumab, and latanoprost were identified as high-association medications. Notably, ophthalmic agents had a significantly shorter induction period than non-ophthalmic drugs (mean 125.9 vs. 298.4 days). These findings underscore the need for vigilant pharmacovigilance and further investigation into the etiology and prevention of drug-related conjunctivitis.
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