Evidence map›Paper›PMID 40251056›Full record

ArticleBritish journal of anaesthesia2025

Mind the messenger: role of extracellular vesicle signalling in postoperative neurocognitive dysfunction.

Samarjit Das, Michael J Devinney, Miles Berger, Charles H Brown

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Exosomes as a biomarker in postoperative complications: a literature review.Frontiers in cell and developmental biology · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samarjit DasDepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael J DevinneyDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
Miles BergerDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Charles H BrownDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: chbrown@stanford.edu.

Funding

Exosome-based Non-traditional Technologies Towards Multi-Parametric andIntegrated Approaches for SARS-CoV-2U18TR003780 · NCATS · JOHNS HOPKINS UNIVERSITY · PI DAS, SAMARJIT · 2021 to 2022
$2.0M
American Heart Association-American Stroke Association 970850NCATS NIH HHS U18 TR003780
6 · The paper itself

Abstract

Extracellular vesicles are secreted by virtually every cell and allow the transfer of bioactive molecules including proteins, nucleic acids, and lipids to other cell types across the body. This study of the role of extracellular vesicles and their cargo in postoperative cognitive dysfunction after hip or knee replacement surgery reports differential protein and microRNA expression in patients with postoperative cognitive decline versus improvement. This small study in a select surgical population highlights the potential for extracellular vesicles and their contents to play a signalling role in postoperative neurocognitive disorders.

Indexed as

Extracellular VesiclesPostoperative Cognitive ComplicationsPostoperative ComplicationsSignal TransductionAgedArthroplasty, Replacement, HipArthroplasty, Replacement, KneeFemaleHumansMaleMicroRNAsMiddle AgedMicroRNAscomplement proteinsexosomesextracellular vesiclesmicroRNApostoperative neurocognitive disordersproteomics

Identifiers

PMID40251056
PMCPMC12106891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.