ArticleJACC. Case reports2025
Pacing Solutions for Immune Checkpoint Myocarditis and Associated Conduction Disorders.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The many faces of atrioventricular block in myocarditis: a case series and proposed clinical strategy highlighting cardiovascular magnetic resonance-guided diagnosis, device selection, and disease monitoring.European heart journal. Case reports · 2026Article
- Cardiac Implantable Electronic Devices in Oncology Patients: Challenges and Management.Journal of cardiovascular electrophysiology · 2026Review
- Immune checkpoint inhibitor-induced myocarditis with atrioventricular conduction abnormalities: a case report.ESMO gastrointestinal oncology · 2026Article
- Immune checkpoint inhibitor-induced cardiotoxicity: from immune mechanisms to clinical surveillance and targeted therapies.Frontiers in cardiovascular medicine · 2026Review
- A review of immune checkpoint inhibitor-associated myocarditis: Epidemiology, pathogenesis, and biomarkers.Human vaccines & immunotherapeutics · 2025Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocarditis is a rare but serious immune-related adverse event associated with immune checkpoint inhibitors. Mortality from immune checkpoint inhibitor associated myocarditis (ICIMy) is high, and developing advanced atrioventricular block is associated with worse mortality. Among a single-center cohort of 103 patients diagnosed with ICIMy, we describe 9 patients who required cardiac pacing for complete heart block. We present our systematic approach to managing ICIMy with advanced atrioventricular block, emphasizing the use of an active fixation right ventricular lead and external pacemaker generator for temporary pacing. This allows for stable and prolonged temporary pacing over a period of 4 to 6 weeks before deciding on implantation of a permanent pacemaker. This strategy has the potential to minimize infection risk by avoiding the need for generator pocket formation while patients are undergoing immunosuppressive therapy for treatment of ICIMy and allows for patient mobility and participation in physical therapy.
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Registered trials
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