ArticleJACC. Case reports2025
Epinephrine-Induced Coronary Vasospasm Exacerbating Type I Myocardial Infarction.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Kounis Syndrome in the Modern Era: A Comprehensive Review of Allergic Acute Coronary Syndromes.Journal of clinical medicine · 2026Review
- Review
- Kounis Syndrome Presenting with Atrial Fibrillation and Shark-Fin ST Elevation After Multiple Bee Stings in an African Patient: A Case Report.International medical case reports journal · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid administration of intramuscular epinephrine is a crucial lifesaving intervention for severe anaphylaxis. Owing to its alpha- and beta-agonistic effects, epinephrine may rarely induce coronary vasospasm leading to myocardial ischemia and infarction, which can be worse in patients with underlying coronary artery disease due to flow-limiting luminal irregularities who are concurrently predisposed to infarction via plaque rupture. We present an exceedingly rare case of a 48-year-old man with undiagnosed coronary artery disease who developed a type 1 ST-segment elevation myocardial infarction preceded by epinephrine-induced coronary artery vasospasm following development of anaphylaxis after administration of intravenous cefepime for the treatment of cellulitis. Our case emphasizes the need for vigilant cardiac monitoring and management of potentially life-threatening cardiac complications when administering empiric epinephrine for anaphylactic shock, especially in patients with risk factors for coronary artery disease.
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Registered trials
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